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Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

BACKGROUND: Cytochrome P450 2D6 (CYP2D6), a member of the CYP450 enzyme super family, is a polymorphic enzyme that metabolizes ~25% of therapeutic drugs. CYP2D6 exhibits significant genetic polymorphisms which might cause adverse effects and therapeutic failures of some drugs. OBJECTIVE: The purpose...

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Detalles Bibliográficos
Autores principales:	Fang, Ping, Zheng, Xiang, He, Jiayang, Ge, Honglei, Tang, Pengfei, Cai, Jianping, Hu, Guoxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407444/ https://www.ncbi.nlm.nih.gov/pubmed/28461741 http://dx.doi.org/10.2147/DDDT.S133814

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