Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen

The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to...

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Autores principales: Ahmed, Tarek, Nash, Anthony, Clark, Kristina EN, Ghibaudo, Marion, de Leeuw, Nora H, Potter, Anne, Stratton, Richard, Birch, Helen L, Enea Casse, Ramona, Bozec, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407446/
https://www.ncbi.nlm.nih.gov/pubmed/28461747
http://dx.doi.org/10.2147/IJN.S121400
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author Ahmed, Tarek
Nash, Anthony
Clark, Kristina EN
Ghibaudo, Marion
de Leeuw, Nora H
Potter, Anne
Stratton, Richard
Birch, Helen L
Enea Casse, Ramona
Bozec, Laurent
author_facet Ahmed, Tarek
Nash, Anthony
Clark, Kristina EN
Ghibaudo, Marion
de Leeuw, Nora H
Potter, Anne
Stratton, Richard
Birch, Helen L
Enea Casse, Ramona
Bozec, Laurent
author_sort Ahmed, Tarek
collection PubMed
description The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to the accumulation of advanced glycation end product (AGE) cross-links, on the nanomechanical properties of the collagen fibril using atomic force microscope nano-indentation. An age-related decrease in the Young’s modulus of the transverse fibril was observed (from 8.11 to 4.19 GPa in young to old volunteers, respectively, P<0.001). It is proposed that this is due to a change in the fibril density caused by age-related differences in water retention within the fibrils. The new collagen–water interaction mechanism was verified by electronic structure calculations, showing it to be energetically feasible.
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spelling pubmed-54074462017-05-01 Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen Ahmed, Tarek Nash, Anthony Clark, Kristina EN Ghibaudo, Marion de Leeuw, Nora H Potter, Anne Stratton, Richard Birch, Helen L Enea Casse, Ramona Bozec, Laurent Int J Nanomedicine Original Research The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to the accumulation of advanced glycation end product (AGE) cross-links, on the nanomechanical properties of the collagen fibril using atomic force microscope nano-indentation. An age-related decrease in the Young’s modulus of the transverse fibril was observed (from 8.11 to 4.19 GPa in young to old volunteers, respectively, P<0.001). It is proposed that this is due to a change in the fibril density caused by age-related differences in water retention within the fibrils. The new collagen–water interaction mechanism was verified by electronic structure calculations, showing it to be energetically feasible. Dove Medical Press 2017-04-21 /pmc/articles/PMC5407446/ /pubmed/28461747 http://dx.doi.org/10.2147/IJN.S121400 Text en © 2017 Ahmed et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ahmed, Tarek
Nash, Anthony
Clark, Kristina EN
Ghibaudo, Marion
de Leeuw, Nora H
Potter, Anne
Stratton, Richard
Birch, Helen L
Enea Casse, Ramona
Bozec, Laurent
Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
title Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
title_full Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
title_fullStr Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
title_full_unstemmed Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
title_short Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
title_sort combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407446/
https://www.ncbi.nlm.nih.gov/pubmed/28461747
http://dx.doi.org/10.2147/IJN.S121400
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