Cargando…
Variable habitat conditions drive species covariation in the human microbiota
Two species with similar resource requirements respond in a characteristic way to variations in their habitat—their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the huma...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407567/ https://www.ncbi.nlm.nih.gov/pubmed/28448493 http://dx.doi.org/10.1371/journal.pcbi.1005435 |
_version_ | 1783232147915538432 |
---|---|
author | Fisher, Charles K. Mora, Thierry Walczak, Aleksandra M. |
author_facet | Fisher, Charles K. Mora, Thierry Walczak, Aleksandra M. |
author_sort | Fisher, Charles K. |
collection | PubMed |
description | Two species with similar resource requirements respond in a characteristic way to variations in their habitat—their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the human population. Our mathematical framework shows that habitat fluctuations are sufficient for explaining intra-bodysite correlations in relative species abundances from the Human Microbiome Project. We explicitly show that the relative abundances of closely related species are positively correlated and can be predicted from taxonomic relationships. We identify a small set of functional pathways related to metabolism and maintenance of the cell wall that form the basis of a common resource sharing niche space of the human microbiota. |
format | Online Article Text |
id | pubmed-5407567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54075672017-05-14 Variable habitat conditions drive species covariation in the human microbiota Fisher, Charles K. Mora, Thierry Walczak, Aleksandra M. PLoS Comput Biol Research Article Two species with similar resource requirements respond in a characteristic way to variations in their habitat—their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the human population. Our mathematical framework shows that habitat fluctuations are sufficient for explaining intra-bodysite correlations in relative species abundances from the Human Microbiome Project. We explicitly show that the relative abundances of closely related species are positively correlated and can be predicted from taxonomic relationships. We identify a small set of functional pathways related to metabolism and maintenance of the cell wall that form the basis of a common resource sharing niche space of the human microbiota. Public Library of Science 2017-04-27 /pmc/articles/PMC5407567/ /pubmed/28448493 http://dx.doi.org/10.1371/journal.pcbi.1005435 Text en © 2017 Fisher et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fisher, Charles K. Mora, Thierry Walczak, Aleksandra M. Variable habitat conditions drive species covariation in the human microbiota |
title | Variable habitat conditions drive species covariation in the human microbiota |
title_full | Variable habitat conditions drive species covariation in the human microbiota |
title_fullStr | Variable habitat conditions drive species covariation in the human microbiota |
title_full_unstemmed | Variable habitat conditions drive species covariation in the human microbiota |
title_short | Variable habitat conditions drive species covariation in the human microbiota |
title_sort | variable habitat conditions drive species covariation in the human microbiota |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407567/ https://www.ncbi.nlm.nih.gov/pubmed/28448493 http://dx.doi.org/10.1371/journal.pcbi.1005435 |
work_keys_str_mv | AT fishercharlesk variablehabitatconditionsdrivespeciescovariationinthehumanmicrobiota AT morathierry variablehabitatconditionsdrivespeciescovariationinthehumanmicrobiota AT walczakaleksandram variablehabitatconditionsdrivespeciescovariationinthehumanmicrobiota |