Cargando…

A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA

N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular enzyme, glutamate carboxypeptidase II (GCPII) in vivo. Inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nonaka, Takahiro, Yamada, Toshihiko, Ishimura, Tatsuhiro, Zuo, Daiying, Moffett, John R, Neale, Joseph H, Yamamoto, Tatsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407666/ https://www.ncbi.nlm.nih.gov/pubmed/28326936 http://dx.doi.org/10.1177/1744806917697008

Ejemplares similares

Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain
por: Yamamoto, Tatsuo, et al.
Publicado: (2008)

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis
por: Hollinger, Kristen R., et al.
Publicado: (2022)

NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation
por: Yamada, Toshihiko, et al.
Publicado: (2012)

Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
por: Knedlík, Tomáš, et al.
Publicado: (2017)

Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model
por: Adedoyin, Mary O, et al.
Publicado: (2010)

The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses
por: Anthonypillai, Christy, et al.
Publicado: (2006)

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration
por: Rais, Rana, et al.
Publicado: (2015)

Purification and Characterization of Plantaricin ZJ5, a New Bacteriocin Produced by Lactobacillus plantarum ZJ5
por: Song, Da-Feng, et al.
Publicado: (2014)

N-Acetylaspartylglutamate (NAAG) Pretreatment Reduces Hypoxic-Ischemic Brain Damage and Oxidative Stress in Neonatal Rats
por: Bratek, Ewelina, et al.
Publicado: (2020)

Formulation of Chemically Defined Media and Growth Evaluation of Ligilactobacillus salivarius ZJ614 and Limosilactobacillus reuteri ZJ625
por: Kwoji, Iliya Dauda, et al.
Publicado: (2022)

Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long‐term benefits in mice with traumatic brain injury
por: Ji, Tongjie, et al.
Publicado: (2023)

Proton magnetic resonance spectroscopy reveals significant decline in the contents of N-acetylaspartylglutamate in the hippocampus of aged healthy subjects
por: Chang, Ruiting, et al.
Publicado: (2016)

Complete Genome Sequence of Vibrio alginolyticus ZJ-T
por: Deng, Yiqin, et al.
Publicado: (2016)

Locus coeruleus complex of the family Delphinidae
por: Sacchini, Simona, et al.
Publicado: (2018)

Locus Coeruleus in Non-Mammalian Vertebrates
por: Wang, Sijia, et al.
Publicado: (2022)

The Locus Coeruleus Noradrenaline System in Delirium
por: Hansen, Niels, et al.
Publicado: (2021)

The locus coeruleus mediates behavioral flexibility
por: McBurney-Lin, Jim, et al.
Publicado: (2022)

Analgesic characteristics of a newly developed α(2)δ ligand, mirogabalin, on inflammatory pain
por: Komatsu, Shuji, et al.
Publicado: (2021)

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
por: Bathla, Shveta, et al.
Publicado: (2023)

Synchronization and spontaneous dynamics in the Locus Coeruleus network
por: Medvedev, Georgi S
Publicado: (2011)

A role for locus coeruleus in Parkinson tremor
por: Isaias, Ioannis U., et al.
Publicado: (2012)

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity
por: Ferrucci, Michela, et al.
Publicado: (2013)

Locus coeruleus and dopaminergic consolidation of everyday memory
por: Takeuchi, Tomonori, et al.
Publicado: (2016)

Locus Coeruleus and Dopamine-Dependent Memory Consolidation
por: Yamasaki, Miwako, et al.
Publicado: (2017)

Divergent influences of the locus coeruleus on migraine pathophysiology
por: Vila-Pueyo, Marta, et al.
Publicado: (2019)

The role of the locus coeruleus in the generation of pathological anxiety
por: Morris, Laurel S., et al.
Publicado: (2020)

Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia
por: Giorgi, Filippo Sean, et al.
Publicado: (2020)

Fast Localization and Sectioning of Mouse Locus Coeruleus
por: Cao, Song, et al.
Publicado: (2020)

Locus coeruleus in memory formation and Alzheimer's disease
por: James, Tony, et al.
Publicado: (2020)

Natural locus coeruleus dynamics during feeding
por: Sciolino, Natale R., et al.
Publicado: (2022)

Properties and modulation of excitatory inputs to the locus coeruleus
por: Barcomb, Kelsey, et al.
Publicado: (2022)

Characterization of the development of Haemonchus contortus ZJ strain from gerbils
por: Yang, Yi, et al.
Publicado: (2017)

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system
por: Watanabe, Moe, et al.
Publicado: (2018)

Failure of a “foolproof” pin-index medical pipeline system
por: Ishimura, Tatsuhiro, et al.
Publicado: (2016)

Tuning arousal with optogenetic modulation of locus coeruleus neurons
por: Carter, Matthew E., et al.
Publicado: (2010)

Modulation of physiological reflexes by pain: role of the locus coeruleus
por: Szabadi, Elemer
Publicado: (2012)

In vivo visualization of age-related differences in the locus coeruleus
por: Liu, Kathy Y., et al.
Publicado: (2019)

Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
por: Wyrofsky, Ryan R., et al.
Publicado: (2019)

Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus
por: Chalermpalanupap, Termpanit, et al.
Publicado: (2017)

The Neuroanatomy of the Reticular Nucleus Locus Coeruleus in Alzheimer’s Disease
por: Giorgi, Filippo S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_apc50asl8ihioukanp4nhd70op