Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion. In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specifi...

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Detalles Bibliográficos
Autores principales: Roomp, Kirsten, Kristinsson, Hjalti, Schvartz, Domitille, Ubhayasekera, Kumari, Sargsyan, Ernest, Manukyan, Levon, Chowdhury, Azazul, Manell, Hannes, Satagopam, Venkata, Groebe, Karlfried, Schneider, Reinhard, Bergquist, Jonas, Sanchez, Jean-Charles, Bergsten, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407795/
https://www.ncbi.nlm.nih.gov/pubmed/28448538
http://dx.doi.org/10.1371/journal.pone.0176391

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