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Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. DESIGN: Bi-directional Mendelian randomiz...

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Autores principales: Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Nystrup Husemoen, Lise Lotte, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E., Linneberg, Allan, Ohlsson, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407807/
https://www.ncbi.nlm.nih.gov/pubmed/28448539
http://dx.doi.org/10.1371/journal.pone.0176277
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author Eriksson, Joel
Haring, Robin
Grarup, Niels
Vandenput, Liesbeth
Wallaschofski, Henri
Lorentzen, Erik
Hansen, Torben
Mellström, Dan
Pedersen, Oluf
Nauck, Matthias
Lorentzon, Mattias
Nystrup Husemoen, Lise Lotte
Völzke, Henry
Karlsson, Magnus
Baumeister, Sebastian E.
Linneberg, Allan
Ohlsson, Claes
author_facet Eriksson, Joel
Haring, Robin
Grarup, Niels
Vandenput, Liesbeth
Wallaschofski, Henri
Lorentzen, Erik
Hansen, Torben
Mellström, Dan
Pedersen, Oluf
Nauck, Matthias
Lorentzon, Mattias
Nystrup Husemoen, Lise Lotte
Völzke, Henry
Karlsson, Magnus
Baumeister, Sebastian E.
Linneberg, Allan
Ohlsson, Claes
author_sort Eriksson, Joel
collection PubMed
description CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42–-0.09, p = 2.8*10(−3)). For a body weight reduction altering the BMI from 30 to 25 kg/m(2), the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.
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spelling pubmed-54078072017-05-14 Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis Eriksson, Joel Haring, Robin Grarup, Niels Vandenput, Liesbeth Wallaschofski, Henri Lorentzen, Erik Hansen, Torben Mellström, Dan Pedersen, Oluf Nauck, Matthias Lorentzon, Mattias Nystrup Husemoen, Lise Lotte Völzke, Henry Karlsson, Magnus Baumeister, Sebastian E. Linneberg, Allan Ohlsson, Claes PLoS One Research Article CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42–-0.09, p = 2.8*10(−3)). For a body weight reduction altering the BMI from 30 to 25 kg/m(2), the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. Public Library of Science 2017-04-27 /pmc/articles/PMC5407807/ /pubmed/28448539 http://dx.doi.org/10.1371/journal.pone.0176277 Text en © 2017 Eriksson et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Eriksson, Joel
Haring, Robin
Grarup, Niels
Vandenput, Liesbeth
Wallaschofski, Henri
Lorentzen, Erik
Hansen, Torben
Mellström, Dan
Pedersen, Oluf
Nauck, Matthias
Lorentzon, Mattias
Nystrup Husemoen, Lise Lotte
Völzke, Henry
Karlsson, Magnus
Baumeister, Sebastian E.
Linneberg, Allan
Ohlsson, Claes
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
title Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
title_full Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
title_fullStr Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
title_full_unstemmed Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
title_short Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
title_sort causal relationship between obesity and serum testosterone status in men: a bi-directional mendelian randomization analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407807/
https://www.ncbi.nlm.nih.gov/pubmed/28448539
http://dx.doi.org/10.1371/journal.pone.0176277
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