A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma

Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g. BRAFV600E). These feat...

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Detalles Bibliográficos
Autores principales: Tomić, Tajana Tešan, Olausson, Josefin, Wilzén, Annica, Sabel, Magnus, Truvé, Katarina, Sjögren, Helene, Dósa, Sándor, Tisell, Magnus, Lannering, Birgitta, Enlund, Fredrik, Martinsson, Tommy, Åman, Pierre, Abel, Frida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407815/
https://www.ncbi.nlm.nih.gov/pubmed/28448514
http://dx.doi.org/10.1371/journal.pone.0175638

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