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Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels
Small molecule inhibitors of site-specific O-glycosylation by the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T) family are currently unavailable but hold promise as therapeutics, especially if selective against individual ppGalNAc-T isozymes. To identify a compound targeting the ppGalNA...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407854/ https://www.ncbi.nlm.nih.gov/pubmed/28362263 http://dx.doi.org/10.7554/eLife.24051 |