Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old...

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Detalles Bibliográficos
Autores principales: McGowan, Aidan, An, Julie Y., Tanakchi, Sally, Maruf, Mahir, Muthigi, Akhil, George, Arvin, Su, Daniel, Merino, Maria J., Linehan, W. Marston, Boyle, Shawna L., Metwalli, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408140/
https://www.ncbi.nlm.nih.gov/pubmed/28462171
http://dx.doi.org/10.1016/j.eucr.2017.03.017
Descripción
Sumario:Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.

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