Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old...

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Autores principales: McGowan, Aidan, An, Julie Y., Tanakchi, Sally, Maruf, Mahir, Muthigi, Akhil, George, Arvin, Su, Daniel, Merino, Maria J., Linehan, W. Marston, Boyle, Shawna L., Metwalli, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408140/
https://www.ncbi.nlm.nih.gov/pubmed/28462171
http://dx.doi.org/10.1016/j.eucr.2017.03.017
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author McGowan, Aidan
An, Julie Y.
Tanakchi, Sally
Maruf, Mahir
Muthigi, Akhil
George, Arvin
Su, Daniel
Merino, Maria J.
Linehan, W. Marston
Boyle, Shawna L.
Metwalli, Adam R.
author_facet McGowan, Aidan
An, Julie Y.
Tanakchi, Sally
Maruf, Mahir
Muthigi, Akhil
George, Arvin
Su, Daniel
Merino, Maria J.
Linehan, W. Marston
Boyle, Shawna L.
Metwalli, Adam R.
author_sort McGowan, Aidan
collection PubMed
description Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.
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spelling pubmed-54081402017-05-01 Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation McGowan, Aidan An, Julie Y. Tanakchi, Sally Maruf, Mahir Muthigi, Akhil George, Arvin Su, Daniel Merino, Maria J. Linehan, W. Marston Boyle, Shawna L. Metwalli, Adam R. Urol Case Rep Oncology Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized. Elsevier 2017-04-27 /pmc/articles/PMC5408140/ /pubmed/28462171 http://dx.doi.org/10.1016/j.eucr.2017.03.017 Text en © 2017 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
McGowan, Aidan
An, Julie Y.
Tanakchi, Sally
Maruf, Mahir
Muthigi, Akhil
George, Arvin
Su, Daniel
Merino, Maria J.
Linehan, W. Marston
Boyle, Shawna L.
Metwalli, Adam R.
Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation
title Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation
title_full Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation
title_fullStr Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation
title_full_unstemmed Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation
title_short Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation
title_sort multiple recurrent paraganglioma in a pediatric patient with germline sdh-b mutation
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408140/
https://www.ncbi.nlm.nih.gov/pubmed/28462171
http://dx.doi.org/10.1016/j.eucr.2017.03.017
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