Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau

A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of R...

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Autores principales: DiBianco, John M., An, Julie Y., Tanakchi, Sally, Stanik, Zachary, McGowan, Aidan, Maruf, Mahir, Sidana, Abhinav, Jain, Amit Lodha, Muthigi, Akhil, George, Arvin K., Bayne, Christopher, Linehan, W. Marston, Boyle, Shawna L., Metwalli, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408158/
https://www.ncbi.nlm.nih.gov/pubmed/28462169
http://dx.doi.org/10.1016/j.eucr.2017.02.015
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author DiBianco, John M.
An, Julie Y.
Tanakchi, Sally
Stanik, Zachary
McGowan, Aidan
Maruf, Mahir
Sidana, Abhinav
Jain, Amit Lodha
Muthigi, Akhil
George, Arvin K.
Bayne, Christopher
Linehan, W. Marston
Boyle, Shawna L.
Metwalli, Adam R.
author_facet DiBianco, John M.
An, Julie Y.
Tanakchi, Sally
Stanik, Zachary
McGowan, Aidan
Maruf, Mahir
Sidana, Abhinav
Jain, Amit Lodha
Muthigi, Akhil
George, Arvin K.
Bayne, Christopher
Linehan, W. Marston
Boyle, Shawna L.
Metwalli, Adam R.
author_sort DiBianco, John M.
collection PubMed
description A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.
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spelling pubmed-54081582017-05-01 Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau DiBianco, John M. An, Julie Y. Tanakchi, Sally Stanik, Zachary McGowan, Aidan Maruf, Mahir Sidana, Abhinav Jain, Amit Lodha Muthigi, Akhil George, Arvin K. Bayne, Christopher Linehan, W. Marston Boyle, Shawna L. Metwalli, Adam R. Urol Case Rep Oncology A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC. Elsevier 2017-04-27 /pmc/articles/PMC5408158/ /pubmed/28462169 http://dx.doi.org/10.1016/j.eucr.2017.02.015 Text en © 2017 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
DiBianco, John M.
An, Julie Y.
Tanakchi, Sally
Stanik, Zachary
McGowan, Aidan
Maruf, Mahir
Sidana, Abhinav
Jain, Amit Lodha
Muthigi, Akhil
George, Arvin K.
Bayne, Christopher
Linehan, W. Marston
Boyle, Shawna L.
Metwalli, Adam R.
Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau
title Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau
title_full Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau
title_fullStr Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau
title_full_unstemmed Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau
title_short Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau
title_sort managing renal cell carcinoma associated paraneoplastic syndrome with nephron-sparing surgery in a patient with von hippel-lindau
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408158/
https://www.ncbi.nlm.nih.gov/pubmed/28462169
http://dx.doi.org/10.1016/j.eucr.2017.02.015
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