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Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358
Recently, the clinical and experimental evidences that support the toxic effects of indoxyl sulfate, a protein-bound uremic toxin in chronic kidney disease (CKD) patients, has been discussed. In this panorama, the authors described several in vitro and in vivo studies, suggesting that indoxyl sulfat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408216/ https://www.ncbi.nlm.nih.gov/pubmed/28420181 http://dx.doi.org/10.3390/toxins9040142 |
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author | Barreto, Fellype C. Barreto, Daniela V. Stinghen, Andrea E. M. Massy, Ziad A. |
author_facet | Barreto, Fellype C. Barreto, Daniela V. Stinghen, Andrea E. M. Massy, Ziad A. |
author_sort | Barreto, Fellype C. |
collection | PubMed |
description | Recently, the clinical and experimental evidences that support the toxic effects of indoxyl sulfate, a protein-bound uremic toxin in chronic kidney disease (CKD) patients, has been discussed. In this panorama, the authors described several in vitro and in vivo studies, suggesting that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease. However, the discussion claims the need for relevant clinical studies in CKD patients whose bone turnover biomarkers and bone histomorphometry were assessed in order to demonstrate the association between serum levels of indoxyl sulfate and bone turnover. We would like to underline the availability of this clinical data to support the concept that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease in CKD patients. |
format | Online Article Text |
id | pubmed-5408216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54082162017-05-03 Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 Barreto, Fellype C. Barreto, Daniela V. Stinghen, Andrea E. M. Massy, Ziad A. Toxins (Basel) Comment Recently, the clinical and experimental evidences that support the toxic effects of indoxyl sulfate, a protein-bound uremic toxin in chronic kidney disease (CKD) patients, has been discussed. In this panorama, the authors described several in vitro and in vivo studies, suggesting that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease. However, the discussion claims the need for relevant clinical studies in CKD patients whose bone turnover biomarkers and bone histomorphometry were assessed in order to demonstrate the association between serum levels of indoxyl sulfate and bone turnover. We would like to underline the availability of this clinical data to support the concept that indoxyl sulfate may play a part in the pathogenesis of low turnover bone disease in CKD patients. MDPI 2017-04-17 /pmc/articles/PMC5408216/ /pubmed/28420181 http://dx.doi.org/10.3390/toxins9040142 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Comment Barreto, Fellype C. Barreto, Daniela V. Stinghen, Andrea E. M. Massy, Ziad A. Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 |
title | Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 |
title_full | Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 |
title_fullStr | Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 |
title_full_unstemmed | Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 |
title_short | Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358 |
title_sort | comment on indoxyl sulfate—review of toxicity and therapeutic strategies. toxins 2016, 8, 358 |
topic | Comment |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408216/ https://www.ncbi.nlm.nih.gov/pubmed/28420181 http://dx.doi.org/10.3390/toxins9040142 |
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