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Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates
In this review, we have attempted to describe all of the antibody–drug conjugates using a marine-derived compound as the “warhead”, that are currently in clinical trials as listed in the current version of the NIH clinical trials database (clinicaltrials.gov). In searching this database, we used the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408245/ https://www.ncbi.nlm.nih.gov/pubmed/28353637 http://dx.doi.org/10.3390/md15040099 |
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author | Newman, David J. Cragg, Gordon M. |
author_facet | Newman, David J. Cragg, Gordon M. |
author_sort | Newman, David J. |
collection | PubMed |
description | In this review, we have attempted to describe all of the antibody–drug conjugates using a marine-derived compound as the “warhead”, that are currently in clinical trials as listed in the current version of the NIH clinical trials database (clinicaltrials.gov). In searching this database, we used the beta-test version currently available, as it permitted more specific search parameters, since the regular version did not always find trials that had been completed in the past with some agents. We also added small discussion sections on candidates that are still at the preclinical stage, including a derivative of diazonamide that has an unusual interaction with tubulin (DZ-23840), which may also be a potential warhead in the future. |
format | Online Article Text |
id | pubmed-5408245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54082452017-05-03 Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates Newman, David J. Cragg, Gordon M. Mar Drugs Review In this review, we have attempted to describe all of the antibody–drug conjugates using a marine-derived compound as the “warhead”, that are currently in clinical trials as listed in the current version of the NIH clinical trials database (clinicaltrials.gov). In searching this database, we used the beta-test version currently available, as it permitted more specific search parameters, since the regular version did not always find trials that had been completed in the past with some agents. We also added small discussion sections on candidates that are still at the preclinical stage, including a derivative of diazonamide that has an unusual interaction with tubulin (DZ-23840), which may also be a potential warhead in the future. MDPI 2017-03-29 /pmc/articles/PMC5408245/ /pubmed/28353637 http://dx.doi.org/10.3390/md15040099 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Newman, David J. Cragg, Gordon M. Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates |
title | Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates |
title_full | Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates |
title_fullStr | Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates |
title_full_unstemmed | Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates |
title_short | Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates |
title_sort | current status of marine-derived compounds as warheads in anti-tumor drug candidates |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408245/ https://www.ncbi.nlm.nih.gov/pubmed/28353637 http://dx.doi.org/10.3390/md15040099 |
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