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Pharmacophore-Based Virtual Screening of Novel Inhibitors and Docking Analysis for CYP51A from Penicillium italicum

Sterol 14α-demethylases from Cytochrome P450 family (CYP51s) are essential enzymes in sterol biosynthesis and well-known as the target of antifungal drugs. The 3D structure of CYP51A from Penicillium italicum (PiCYP51A) was constructed through homology modeling based on the crystal structure of huma...

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Detalles Bibliográficos
Autores principales:	Yuan, Yongze, Han, Rui, Cao, Qianwen, Yu, Jinhui, Mao, Jiali, Zhang, Tingfu, Wang, Shengqiang, Niu, Yuhui, Liu, Deli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408253/ https://www.ncbi.nlm.nih.gov/pubmed/28379163 http://dx.doi.org/10.3390/md15040107

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