An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.

Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and...

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Detalles Bibliográficos
Autores principales: Tomura, Tomohiko, Nagashima, Shiori, Yamazaki, Satoshi, Iizuka, Takashi, Fudou, Ryosuke, Ojika, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408255/
https://www.ncbi.nlm.nih.gov/pubmed/28383484
http://dx.doi.org/10.3390/md15040109
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author Tomura, Tomohiko
Nagashima, Shiori
Yamazaki, Satoshi
Iizuka, Takashi
Fudou, Ryosuke
Ojika, Makoto
author_facet Tomura, Tomohiko
Nagashima, Shiori
Yamazaki, Satoshi
Iizuka, Takashi
Fudou, Ryosuke
Ojika, Makoto
author_sort Tomura, Tomohiko
collection PubMed
description Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells.
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spelling pubmed-54082552017-05-03 An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp. Tomura, Tomohiko Nagashima, Shiori Yamazaki, Satoshi Iizuka, Takashi Fudou, Ryosuke Ojika, Makoto Mar Drugs Article Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells. MDPI 2017-04-06 /pmc/articles/PMC5408255/ /pubmed/28383484 http://dx.doi.org/10.3390/md15040109 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tomura, Tomohiko
Nagashima, Shiori
Yamazaki, Satoshi
Iizuka, Takashi
Fudou, Ryosuke
Ojika, Makoto
An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_full An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_fullStr An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_full_unstemmed An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_short An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_sort unusual diterpene—enhygromic acid and deoxyenhygrolides from a marine myxobacterium, enhygromyxa sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408255/
https://www.ncbi.nlm.nih.gov/pubmed/28383484
http://dx.doi.org/10.3390/md15040109
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