Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysi...

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Detalles Bibliográficos
Autores principales: Hermawan, Idam, Furuta, Atsushi, Higashi, Masahiro, Fujita, Yoshihisa, Akimitsu, Nobuyoshi, Yamashita, Atsuya, Moriishi, Kohji, Tsuneda, Satoshi, Tani, Hidenori, Nakakoshi, Masamichi, Tsubuki, Masayoshi, Sekiguchi, Yuji, Noda, Naohiro, Tanaka, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408263/
https://www.ncbi.nlm.nih.gov/pubmed/28398249
http://dx.doi.org/10.3390/md15040117
Descripción
Sumario:Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1–4 showed moderate inhibition against NS3 helicase with IC(50) values of 71, 95, 7, and 5 μM, respectively.

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