Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysi...

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Autores principales: Hermawan, Idam, Furuta, Atsushi, Higashi, Masahiro, Fujita, Yoshihisa, Akimitsu, Nobuyoshi, Yamashita, Atsuya, Moriishi, Kohji, Tsuneda, Satoshi, Tani, Hidenori, Nakakoshi, Masamichi, Tsubuki, Masayoshi, Sekiguchi, Yuji, Noda, Naohiro, Tanaka, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408263/
https://www.ncbi.nlm.nih.gov/pubmed/28398249
http://dx.doi.org/10.3390/md15040117
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author Hermawan, Idam
Furuta, Atsushi
Higashi, Masahiro
Fujita, Yoshihisa
Akimitsu, Nobuyoshi
Yamashita, Atsuya
Moriishi, Kohji
Tsuneda, Satoshi
Tani, Hidenori
Nakakoshi, Masamichi
Tsubuki, Masayoshi
Sekiguchi, Yuji
Noda, Naohiro
Tanaka, Junichi
author_facet Hermawan, Idam
Furuta, Atsushi
Higashi, Masahiro
Fujita, Yoshihisa
Akimitsu, Nobuyoshi
Yamashita, Atsuya
Moriishi, Kohji
Tsuneda, Satoshi
Tani, Hidenori
Nakakoshi, Masamichi
Tsubuki, Masayoshi
Sekiguchi, Yuji
Noda, Naohiro
Tanaka, Junichi
author_sort Hermawan, Idam
collection PubMed
description Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1–4 showed moderate inhibition against NS3 helicase with IC(50) values of 71, 95, 7, and 5 μM, respectively.
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spelling pubmed-54082632017-05-03 Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia Hermawan, Idam Furuta, Atsushi Higashi, Masahiro Fujita, Yoshihisa Akimitsu, Nobuyoshi Yamashita, Atsuya Moriishi, Kohji Tsuneda, Satoshi Tani, Hidenori Nakakoshi, Masamichi Tsubuki, Masayoshi Sekiguchi, Yuji Noda, Naohiro Tanaka, Junichi Mar Drugs Article Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1–4 showed moderate inhibition against NS3 helicase with IC(50) values of 71, 95, 7, and 5 μM, respectively. MDPI 2017-04-11 /pmc/articles/PMC5408263/ /pubmed/28398249 http://dx.doi.org/10.3390/md15040117 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hermawan, Idam
Furuta, Atsushi
Higashi, Masahiro
Fujita, Yoshihisa
Akimitsu, Nobuyoshi
Yamashita, Atsuya
Moriishi, Kohji
Tsuneda, Satoshi
Tani, Hidenori
Nakakoshi, Masamichi
Tsubuki, Masayoshi
Sekiguchi, Yuji
Noda, Naohiro
Tanaka, Junichi
Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia
title Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia
title_full Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia
title_fullStr Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia
title_full_unstemmed Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia
title_short Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia
title_sort four aromatic sulfates with an inhibitory effect against hcv ns3 helicase from the crinoid alloeocomatella polycladia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408263/
https://www.ncbi.nlm.nih.gov/pubmed/28398249
http://dx.doi.org/10.3390/md15040117
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