In Vivo Activation of Duocarmycin–Antibody Conjugates by Near-Infrared Light

[Image: see text] Near-IR photocaging groups based on the heptamethine cyanine scaffold present the opportunity to visualize and then treat diseased tissue with potent bioactive molecules. Here we describe fundamental chemical studies that enable biological validation of this approach. Guided by rat...

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Detalles Bibliográficos
Autores principales: Nani, Roger R., Gorka, Alexander P., Nagaya, Tadanobu, Yamamoto, Tsuyoshi, Ivanic, Joseph, Kobayashi, Hisataka, Schnermann, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408340/
https://www.ncbi.nlm.nih.gov/pubmed/28470051
http://dx.doi.org/10.1021/acscentsci.7b00026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408340/
https://www.ncbi.nlm.nih.gov/pubmed/28470051
http://dx.doi.org/10.1021/acscentsci.7b00026

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