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In Vivo Activation of Duocarmycin–Antibody Conjugates by Near-Infrared Light
[Image: see text] Near-IR photocaging groups based on the heptamethine cyanine scaffold present the opportunity to visualize and then treat diseased tissue with potent bioactive molecules. Here we describe fundamental chemical studies that enable biological validation of this approach. Guided by rat...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408340/ https://www.ncbi.nlm.nih.gov/pubmed/28470051 http://dx.doi.org/10.1021/acscentsci.7b00026 |