Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity

Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance...

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Detalles Bibliográficos
Autores principales: Mu, Chaojing, Wu, Qingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408359/
https://www.ncbi.nlm.nih.gov/pubmed/28460490
http://dx.doi.org/10.1186/s11671-017-2092-y
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author Mu, Chaojing
Wu, Qingsheng
author_facet Mu, Chaojing
Wu, Qingsheng
author_sort Mu, Chaojing
collection PubMed
description Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis-DIDP were reduced greatly. In vitro, cis-DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis-DIDP, even better than cisplatin. Furthermore, cis-DIDP@PCL could controllably release cis-DIDP in different sustained-release solution based on our experiment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-017-2092-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-54083592017-05-15 Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity Mu, Chaojing Wu, Qingsheng Nanoscale Res Lett Nano Express Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis-DIDP were reduced greatly. In vitro, cis-DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis-DIDP, even better than cisplatin. Furthermore, cis-DIDP@PCL could controllably release cis-DIDP in different sustained-release solution based on our experiment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-017-2092-y) contains supplementary material, which is available to authorized users. Springer US 2017-04-28 /pmc/articles/PMC5408359/ /pubmed/28460490 http://dx.doi.org/10.1186/s11671-017-2092-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Mu, Chaojing
Wu, Qingsheng
Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
title Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
title_full Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
title_fullStr Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
title_full_unstemmed Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
title_short Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
title_sort electrospun poly(ε-caprolactone) composite nanofibers with controlled release of cis-diamminediiodoplatinum for a higher anticancer activity
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408359/
https://www.ncbi.nlm.nih.gov/pubmed/28460490
http://dx.doi.org/10.1186/s11671-017-2092-y
work_keys_str_mv AT muchaojing electrospunpolyecaprolactonecompositenanofiberswithcontrolledreleaseofcisdiamminediiodoplatinumforahigheranticanceractivity
AT wuqingsheng electrospunpolyecaprolactonecompositenanofiberswithcontrolledreleaseofcisdiamminediiodoplatinumforahigheranticanceractivity

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