Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM

The effect of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the Multiple Sclerosis Functional Composite (MSFC) was assessed using integrated Phase 3 DEFINE and CONFIRM data. Patients treated with DMF (n = 769) demonstrated significant superiority on the MSFC, and eac...

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Autores principales: Giovannoni, Gavin, Gold, Ralf, Kappos, Ludwig, Arnold, Douglas L, Bar-Or, Amit, Marantz, Jing L, Yang, Minhua, Lee, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408570/
https://www.ncbi.nlm.nih.gov/pubmed/28607719
http://dx.doi.org/10.1177/2055217316634111
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author Giovannoni, Gavin
Gold, Ralf
Kappos, Ludwig
Arnold, Douglas L
Bar-Or, Amit
Marantz, Jing L
Yang, Minhua
Lee, Andrew
author_facet Giovannoni, Gavin
Gold, Ralf
Kappos, Ludwig
Arnold, Douglas L
Bar-Or, Amit
Marantz, Jing L
Yang, Minhua
Lee, Andrew
author_sort Giovannoni, Gavin
collection PubMed
description The effect of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the Multiple Sclerosis Functional Composite (MSFC) was assessed using integrated Phase 3 DEFINE and CONFIRM data. Patients treated with DMF (n = 769) demonstrated significant superiority on the MSFC, and each component, compared with placebo (n = 771) over two years: mean change for DMF vs placebo was 0.054 vs −0.053 on MSFC; −0.088 vs −0.286 on Timed 25-Foot Walk, 0.047 vs 0.003 on 9-Hole Peg Test and 0.178 vs 0.123 on Paced Auditory Serial Addition Test. DMF was an efficacious treatment for patients with MS.
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spelling pubmed-54085702017-06-12 Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM Giovannoni, Gavin Gold, Ralf Kappos, Ludwig Arnold, Douglas L Bar-Or, Amit Marantz, Jing L Yang, Minhua Lee, Andrew Mult Scler J Exp Transl Clin Short Report The effect of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the Multiple Sclerosis Functional Composite (MSFC) was assessed using integrated Phase 3 DEFINE and CONFIRM data. Patients treated with DMF (n = 769) demonstrated significant superiority on the MSFC, and each component, compared with placebo (n = 771) over two years: mean change for DMF vs placebo was 0.054 vs −0.053 on MSFC; −0.088 vs −0.286 on Timed 25-Foot Walk, 0.047 vs 0.003 on 9-Hole Peg Test and 0.178 vs 0.123 on Paced Auditory Serial Addition Test. DMF was an efficacious treatment for patients with MS. SAGE Publications 2016-02-19 /pmc/articles/PMC5408570/ /pubmed/28607719 http://dx.doi.org/10.1177/2055217316634111 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Report
Giovannoni, Gavin
Gold, Ralf
Kappos, Ludwig
Arnold, Douglas L
Bar-Or, Amit
Marantz, Jing L
Yang, Minhua
Lee, Andrew
Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
title Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
title_full Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
title_fullStr Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
title_full_unstemmed Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
title_short Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
title_sort delayed-release dimethyl fumarate and disability assessed by the multiple sclerosis functional composite: integrated analysis of define and confirm
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408570/
https://www.ncbi.nlm.nih.gov/pubmed/28607719
http://dx.doi.org/10.1177/2055217316634111
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