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A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance
Marek’s disease (MD) virus (MDV) has been evolving continuously, leading to increasing vaccination failure. Here, the MDV field strain BS/15 was isolated from a severely diseased Chinese chicken flock previously vaccinated with CVI988. To explore the causes of vaccination failure, specific-pathogen...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408677/ https://www.ncbi.nlm.nih.gov/pubmed/28368367 http://dx.doi.org/10.3390/v9040071 |
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author | Sun, Guo-rong Zhang, Yan-ping Lv, Hong-chao Zhou, Lin-yi Cui, Hong-yu Gao, Yu-long Qi, Xiao-le Wang, Yong-qiang Li, Kai Gao, Li Pan, Qing Wang, Xiao-mei Liu, Chang-jun |
author_facet | Sun, Guo-rong Zhang, Yan-ping Lv, Hong-chao Zhou, Lin-yi Cui, Hong-yu Gao, Yu-long Qi, Xiao-le Wang, Yong-qiang Li, Kai Gao, Li Pan, Qing Wang, Xiao-mei Liu, Chang-jun |
author_sort | Sun, Guo-rong |
collection | PubMed |
description | Marek’s disease (MD) virus (MDV) has been evolving continuously, leading to increasing vaccination failure. Here, the MDV field strain BS/15 was isolated from a severely diseased Chinese chicken flock previously vaccinated with CVI988. To explore the causes of vaccination failure, specific-pathogen free (SPF) chickens vaccinated with CVI988 or 814 and unvaccinated controls were challenged with either BS/15 or the reference strain Md5. Both strains induced MD lesions in unvaccinated chickens with similar mortality rates of 85.7% and 80.0% during the experimental period, respectively. However, unvaccinated chickens inoculated with BS/15 exhibited a higher tumor development rate (64.3% vs. 40.0%), but prolonged survival and diminished immune defects compared to Md5-challenged counterparts. These results suggest that BS/15 and Md5 show a similar virulence but manifest with different pathogenic characteristics. Moreover, the protective indices of CVI988 and 814 were 33.3 and 66.7 for BS/15, and 92.9 and 100 for Md5, respectively, indicating that neither vaccine could provide efficient protection against BS/15. Taken together, these data suggest that MD vaccination failure is probably due to the existence of variant MDV strains with known virulence and unexpected vaccine resistance. Our findings should be helpful for understanding the pathogenicity and evolution of MDV strains prevalent in China. |
format | Online Article Text |
id | pubmed-5408677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54086772017-05-18 A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance Sun, Guo-rong Zhang, Yan-ping Lv, Hong-chao Zhou, Lin-yi Cui, Hong-yu Gao, Yu-long Qi, Xiao-le Wang, Yong-qiang Li, Kai Gao, Li Pan, Qing Wang, Xiao-mei Liu, Chang-jun Viruses Article Marek’s disease (MD) virus (MDV) has been evolving continuously, leading to increasing vaccination failure. Here, the MDV field strain BS/15 was isolated from a severely diseased Chinese chicken flock previously vaccinated with CVI988. To explore the causes of vaccination failure, specific-pathogen free (SPF) chickens vaccinated with CVI988 or 814 and unvaccinated controls were challenged with either BS/15 or the reference strain Md5. Both strains induced MD lesions in unvaccinated chickens with similar mortality rates of 85.7% and 80.0% during the experimental period, respectively. However, unvaccinated chickens inoculated with BS/15 exhibited a higher tumor development rate (64.3% vs. 40.0%), but prolonged survival and diminished immune defects compared to Md5-challenged counterparts. These results suggest that BS/15 and Md5 show a similar virulence but manifest with different pathogenic characteristics. Moreover, the protective indices of CVI988 and 814 were 33.3 and 66.7 for BS/15, and 92.9 and 100 for Md5, respectively, indicating that neither vaccine could provide efficient protection against BS/15. Taken together, these data suggest that MD vaccination failure is probably due to the existence of variant MDV strains with known virulence and unexpected vaccine resistance. Our findings should be helpful for understanding the pathogenicity and evolution of MDV strains prevalent in China. MDPI 2017-04-03 /pmc/articles/PMC5408677/ /pubmed/28368367 http://dx.doi.org/10.3390/v9040071 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Guo-rong Zhang, Yan-ping Lv, Hong-chao Zhou, Lin-yi Cui, Hong-yu Gao, Yu-long Qi, Xiao-le Wang, Yong-qiang Li, Kai Gao, Li Pan, Qing Wang, Xiao-mei Liu, Chang-jun A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance |
title | A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance |
title_full | A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance |
title_fullStr | A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance |
title_full_unstemmed | A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance |
title_short | A Chinese Variant Marek’s Disease Virus Strain with Divergence between Virulence and Vaccine Resistance |
title_sort | chinese variant marek’s disease virus strain with divergence between virulence and vaccine resistance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408677/ https://www.ncbi.nlm.nih.gov/pubmed/28368367 http://dx.doi.org/10.3390/v9040071 |
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