Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis

Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (...

Descripción completa

Detalles Bibliográficos
Autores principales: Herfs, Michael, Soong, Thing R., Delvenne, Philippe, Crum, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408691/
https://www.ncbi.nlm.nih.gov/pubmed/28425968
http://dx.doi.org/10.3390/v9040085
_version_ 1783232349125738496
author Herfs, Michael
Soong, Thing R.
Delvenne, Philippe
Crum, Christopher P.
author_facet Herfs, Michael
Soong, Thing R.
Delvenne, Philippe
Crum, Christopher P.
author_sort Herfs, Michael
collection PubMed
description Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (SC) junction cells in the pathogenesis of cervical (pre)cancers. The present review summarizes the current knowledge on junctional cells, discusses their high vulnerability to HPV infection, and stresses the potential clinical/translational value of the novel dualistic model of HPV-related carcinogenesis.
format Online
Article
Text
id pubmed-5408691
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-54086912017-05-18 Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis Herfs, Michael Soong, Thing R. Delvenne, Philippe Crum, Christopher P. Viruses Review Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (SC) junction cells in the pathogenesis of cervical (pre)cancers. The present review summarizes the current knowledge on junctional cells, discusses their high vulnerability to HPV infection, and stresses the potential clinical/translational value of the novel dualistic model of HPV-related carcinogenesis. MDPI 2017-04-20 /pmc/articles/PMC5408691/ /pubmed/28425968 http://dx.doi.org/10.3390/v9040085 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herfs, Michael
Soong, Thing R.
Delvenne, Philippe
Crum, Christopher P.
Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
title Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
title_full Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
title_fullStr Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
title_full_unstemmed Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
title_short Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
title_sort deciphering the multifactorial susceptibility of mucosal junction cells to hpv infection and related carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408691/
https://www.ncbi.nlm.nih.gov/pubmed/28425968
http://dx.doi.org/10.3390/v9040085
work_keys_str_mv AT herfsmichael decipheringthemultifactorialsusceptibilityofmucosaljunctioncellstohpvinfectionandrelatedcarcinogenesis
AT soongthingr decipheringthemultifactorialsusceptibilityofmucosaljunctioncellstohpvinfectionandrelatedcarcinogenesis
AT delvennephilippe decipheringthemultifactorialsusceptibilityofmucosaljunctioncellstohpvinfectionandrelatedcarcinogenesis
AT crumchristopherp decipheringthemultifactorialsusceptibilityofmucosaljunctioncellstohpvinfectionandrelatedcarcinogenesis

Ejemplares similares