GENIUS: web server to predict local gene networks and key genes for biological functions

SUMMARY: GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from spec...

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Detalles Bibliográficos
Autores principales: Puelma, Tomas, Araus, Viviana, Canales, Javier, Vidal, Elena A, Cabello, Juan M, Soto, Alvaro, Gutiérrez, Rodrigo A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408817/
https://www.ncbi.nlm.nih.gov/pubmed/27993775
http://dx.doi.org/10.1093/bioinformatics/btw702
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author Puelma, Tomas
Araus, Viviana
Canales, Javier
Vidal, Elena A
Cabello, Juan M
Soto, Alvaro
Gutiérrez, Rodrigo A
author_facet Puelma, Tomas
Araus, Viviana
Canales, Javier
Vidal, Elena A
Cabello, Juan M
Soto, Alvaro
Gutiérrez, Rodrigo A
author_sort Puelma, Tomas
collection PubMed
description SUMMARY: GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from specific biological processes to complex traits that involve several interacting processes. GENIUS also enriches the network with new genes related to the biological function of interest, with accuracies comparable to highly discriminative Support Vector Machine methods. AVAILABILITY AND IMPLEMENTATION: GENIUS currently supports eight model organisms and is freely available for public use at http://networks.bio.puc.cl/genius. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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spelling pubmed-54088172017-05-03 GENIUS: web server to predict local gene networks and key genes for biological functions Puelma, Tomas Araus, Viviana Canales, Javier Vidal, Elena A Cabello, Juan M Soto, Alvaro Gutiérrez, Rodrigo A Bioinformatics Applications Notes SUMMARY: GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from specific biological processes to complex traits that involve several interacting processes. GENIUS also enriches the network with new genes related to the biological function of interest, with accuracies comparable to highly discriminative Support Vector Machine methods. AVAILABILITY AND IMPLEMENTATION: GENIUS currently supports eight model organisms and is freely available for public use at http://networks.bio.puc.cl/genius. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Oxford University Press 2017-03-01 2016-11-30 /pmc/articles/PMC5408817/ /pubmed/27993775 http://dx.doi.org/10.1093/bioinformatics/btw702 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Puelma, Tomas
Araus, Viviana
Canales, Javier
Vidal, Elena A
Cabello, Juan M
Soto, Alvaro
Gutiérrez, Rodrigo A
GENIUS: web server to predict local gene networks and key genes for biological functions
title GENIUS: web server to predict local gene networks and key genes for biological functions
title_full GENIUS: web server to predict local gene networks and key genes for biological functions
title_fullStr GENIUS: web server to predict local gene networks and key genes for biological functions
title_full_unstemmed GENIUS: web server to predict local gene networks and key genes for biological functions
title_short GENIUS: web server to predict local gene networks and key genes for biological functions
title_sort genius: web server to predict local gene networks and key genes for biological functions
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408817/
https://www.ncbi.nlm.nih.gov/pubmed/27993775
http://dx.doi.org/10.1093/bioinformatics/btw702
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