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Neurological complications and death in children with dengue virus infection: report of two cases

BACKGROUND: Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurological manifestations can be confused with encephalitis symptoms and can lead to cer...

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Autores principales: Osnaya-Romero, Neydi, Perez-Guille, Maria-Gabriela, Andrade-García, Sandra, Gonzalez-Vargas, Erika, Borgaro-Payro, Rebeca, Villagomez-Martinez, Sandra, de Jesús Ortega-Maldonado, José, Arredondo-García, Jose Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408821/
https://www.ncbi.nlm.nih.gov/pubmed/28465676
http://dx.doi.org/10.1186/s40409-017-0115-x
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author Osnaya-Romero, Neydi
Perez-Guille, Maria-Gabriela
Andrade-García, Sandra
Gonzalez-Vargas, Erika
Borgaro-Payro, Rebeca
Villagomez-Martinez, Sandra
de Jesús Ortega-Maldonado, José
Arredondo-García, Jose Luis
author_facet Osnaya-Romero, Neydi
Perez-Guille, Maria-Gabriela
Andrade-García, Sandra
Gonzalez-Vargas, Erika
Borgaro-Payro, Rebeca
Villagomez-Martinez, Sandra
de Jesús Ortega-Maldonado, José
Arredondo-García, Jose Luis
author_sort Osnaya-Romero, Neydi
collection PubMed
description BACKGROUND: Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurological manifestations can be confused with encephalitis symptoms and can lead to cerebral edema and death. Therefore, we consider important in the endemic areas to take into account the diagnosis of dengue encephalitis in patients with neurological disorders, and to request the determination of serology in cerebrospinal fluid for the NS1 antigen test. CASE PRESENTATION: We present the cases of two patients from the state of Morelos, Mexico, with 17 and 14 years of age. Both cases presented a rapid evolution characterized by fever, seizures and neurological deterioration secondary to severe cerebral edema that evolved to cerebral death in both cases. The diagnosis of brain death was confirmed by electroencephalogram in both patients. The two patients were submitted to serology for NS1 that tested positive in both cases. They died between the second and fifth day after admission. CONCLUSIONS: Retrospective studies have found that up to 4% of the patients have dengue virus infections, which leads us to believe that in endemic areas, this infection should be suspected in cases of encephalic and febrile symptoms. RT-PCR should be performed to identify cases of encephalitis caused by the dengue virus, and early interventions should be performed to attempt to reduce the morbidity and mortality of these cases.
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spelling pubmed-54088212017-05-02 Neurological complications and death in children with dengue virus infection: report of two cases Osnaya-Romero, Neydi Perez-Guille, Maria-Gabriela Andrade-García, Sandra Gonzalez-Vargas, Erika Borgaro-Payro, Rebeca Villagomez-Martinez, Sandra de Jesús Ortega-Maldonado, José Arredondo-García, Jose Luis J Venom Anim Toxins Incl Trop Dis Case Report BACKGROUND: Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurological manifestations can be confused with encephalitis symptoms and can lead to cerebral edema and death. Therefore, we consider important in the endemic areas to take into account the diagnosis of dengue encephalitis in patients with neurological disorders, and to request the determination of serology in cerebrospinal fluid for the NS1 antigen test. CASE PRESENTATION: We present the cases of two patients from the state of Morelos, Mexico, with 17 and 14 years of age. Both cases presented a rapid evolution characterized by fever, seizures and neurological deterioration secondary to severe cerebral edema that evolved to cerebral death in both cases. The diagnosis of brain death was confirmed by electroencephalogram in both patients. The two patients were submitted to serology for NS1 that tested positive in both cases. They died between the second and fifth day after admission. CONCLUSIONS: Retrospective studies have found that up to 4% of the patients have dengue virus infections, which leads us to believe that in endemic areas, this infection should be suspected in cases of encephalic and febrile symptoms. RT-PCR should be performed to identify cases of encephalitis caused by the dengue virus, and early interventions should be performed to attempt to reduce the morbidity and mortality of these cases. BioMed Central 2017-04-27 /pmc/articles/PMC5408821/ /pubmed/28465676 http://dx.doi.org/10.1186/s40409-017-0115-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Osnaya-Romero, Neydi
Perez-Guille, Maria-Gabriela
Andrade-García, Sandra
Gonzalez-Vargas, Erika
Borgaro-Payro, Rebeca
Villagomez-Martinez, Sandra
de Jesús Ortega-Maldonado, José
Arredondo-García, Jose Luis
Neurological complications and death in children with dengue virus infection: report of two cases
title Neurological complications and death in children with dengue virus infection: report of two cases
title_full Neurological complications and death in children with dengue virus infection: report of two cases
title_fullStr Neurological complications and death in children with dengue virus infection: report of two cases
title_full_unstemmed Neurological complications and death in children with dengue virus infection: report of two cases
title_short Neurological complications and death in children with dengue virus infection: report of two cases
title_sort neurological complications and death in children with dengue virus infection: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408821/
https://www.ncbi.nlm.nih.gov/pubmed/28465676
http://dx.doi.org/10.1186/s40409-017-0115-x
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