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The impact of rare and low-frequency genetic variants in common disease

Despite thousands of genetic loci identified to date, a large proportion of genetic variation predisposing to complex disease and traits remains unaccounted for. Advances in sequencing technology enable focused explorations on the contribution of low-frequency and rare variants to human traits. Here...

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Detalles Bibliográficos
Autores principales:	Bomba, Lorenzo, Walter, Klaudia, Soranzo, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408830/ https://www.ncbi.nlm.nih.gov/pubmed/28449691 http://dx.doi.org/10.1186/s13059-017-1212-4

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