dAPE: a web server to detect homorepeats and follow their evolution

SUMMARY: Homorepeats are low complexity regions consisting of repetitions of a single amino acid residue. There is no current consensus on the minimum number of residues needed to define a functional homorepeat, nor even if mismatches are allowed. Here we present dAPE, a web server that helps follow...

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Detalles Bibliográficos
Autores principales: Mier, Pablo, Andrade-Navarro, Miguel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408840/
https://www.ncbi.nlm.nih.gov/pubmed/28031183
http://dx.doi.org/10.1093/bioinformatics/btw790
Descripción
Sumario:SUMMARY: Homorepeats are low complexity regions consisting of repetitions of a single amino acid residue. There is no current consensus on the minimum number of residues needed to define a functional homorepeat, nor even if mismatches are allowed. Here we present dAPE, a web server that helps following the evolution of homorepeats based on orthology information, using a sensitive but tunable cutoff to help in the identification of emerging homorepeats. AVAILABILITY AND IMPLEMENTATION: dAPE can be accessed from http://cbdm-01.zdv.uni-mainz.de/∼munoz/polyx. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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