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Biomartr: genomic data retrieval with R

MOTIVATION: Retrieval and reproducible functional annotation of genomic data are crucial in biology. However, the current poor usability and transparency of retrieval methods hinders reproducibility. Here we present an open source R package, biomartr, which provides a comprehensive easy-to-use frame...

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Detalles Bibliográficos
Autores principales: Drost, Hajk-Georg, Paszkowski, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408848/
https://www.ncbi.nlm.nih.gov/pubmed/28110292
http://dx.doi.org/10.1093/bioinformatics/btw821
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author Drost, Hajk-Georg
Paszkowski, Jerzy
author_facet Drost, Hajk-Georg
Paszkowski, Jerzy
author_sort Drost, Hajk-Georg
collection PubMed
description MOTIVATION: Retrieval and reproducible functional annotation of genomic data are crucial in biology. However, the current poor usability and transparency of retrieval methods hinders reproducibility. Here we present an open source R package, biomartr, which provides a comprehensive easy-to-use framework for automating data retrieval and functional annotation for meta-genomic approaches. The functions of biomartr achieve a high degree of clarity, transparency and reproducibility of analyses. RESULTS: The biomartr package implements straightforward functions for bulk retrieval of all genomic data or data for selected genomes, proteomes, coding sequences and annotation files present in databases hosted by the National Center for Biotechnology Information (NCBI) and European Bioinformatics Institute (EMBL-EBI). In addition, biomartr communicates with the BioMart database for functional annotation of retrieved sequences. Comprehensive documentation of biomartr functions and five tutorial vignettes provide step-by-step instructions on how to use the package in a reproducible manner. AVAILABILITY AND IMPLEMENTATION: The open source biomartr package is available at https://github.com/HajkD/biomartr and https://cran.r-project.org/web/packages/biomartr/index.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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spelling pubmed-54088482017-05-03 Biomartr: genomic data retrieval with R Drost, Hajk-Georg Paszkowski, Jerzy Bioinformatics Applications Notes MOTIVATION: Retrieval and reproducible functional annotation of genomic data are crucial in biology. However, the current poor usability and transparency of retrieval methods hinders reproducibility. Here we present an open source R package, biomartr, which provides a comprehensive easy-to-use framework for automating data retrieval and functional annotation for meta-genomic approaches. The functions of biomartr achieve a high degree of clarity, transparency and reproducibility of analyses. RESULTS: The biomartr package implements straightforward functions for bulk retrieval of all genomic data or data for selected genomes, proteomes, coding sequences and annotation files present in databases hosted by the National Center for Biotechnology Information (NCBI) and European Bioinformatics Institute (EMBL-EBI). In addition, biomartr communicates with the BioMart database for functional annotation of retrieved sequences. Comprehensive documentation of biomartr functions and five tutorial vignettes provide step-by-step instructions on how to use the package in a reproducible manner. AVAILABILITY AND IMPLEMENTATION: The open source biomartr package is available at https://github.com/HajkD/biomartr and https://cran.r-project.org/web/packages/biomartr/index.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Oxford University Press 2017-04-15 2017-01-20 /pmc/articles/PMC5408848/ /pubmed/28110292 http://dx.doi.org/10.1093/bioinformatics/btw821 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Drost, Hajk-Georg
Paszkowski, Jerzy
Biomartr: genomic data retrieval with R
title Biomartr: genomic data retrieval with R
title_full Biomartr: genomic data retrieval with R
title_fullStr Biomartr: genomic data retrieval with R
title_full_unstemmed Biomartr: genomic data retrieval with R
title_short Biomartr: genomic data retrieval with R
title_sort biomartr: genomic data retrieval with r
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408848/
https://www.ncbi.nlm.nih.gov/pubmed/28110292
http://dx.doi.org/10.1093/bioinformatics/btw821
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