Cargando…
Structural insight to mutation effects uncover a common allosteric site in class C GPCRs
MOTIVATION: Class C G protein-coupled receptors (GPCRs) regulate important physiological functions and allosteric modulators binding to the transmembrane domain constitute an attractive and, due to a lack of structural insight, a virtually unexplored potential for therapeutics and the food industry....
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408886/ https://www.ncbi.nlm.nih.gov/pubmed/28011766 http://dx.doi.org/10.1093/bioinformatics/btw784 |