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Tipifarnib prevents development of hypoxia-induced pulmonary hypertension

AIMS: RhoB plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension. Farnesylated RhoB promotes growth responses in cancer cells and we investigated whether inhibition of protein farnesylation will have a protective effect. METHODS AND RESULTS: The analysis of lung tissues from...

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Detalles Bibliográficos
Autores principales:	Duluc, Lucie, Ahmetaj-Shala, Blerina, Mitchell, Jane, Abdul-Salam, Vahitha B., Mahomed, Abdul S., Aldabbous, Lulwah, Oliver, Eduardo, Iannone, Lucio, Dubois, Olivier D., Storck, Elisabeth M., Tate, Edward W., Zhao, Lan, Wilkins, Martin R., Wojciak-Stothard, Beata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408956/ https://www.ncbi.nlm.nih.gov/pubmed/28395021 http://dx.doi.org/10.1093/cvr/cvw258

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