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High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring

Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild MTHFR deficiency (677C > T polymorphism) increases risk for complex traits, including neuropsychiatric disorder...

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Detalles Bibliográficos
Autores principales:	Bahous, Renata H., Jadavji, Nafisa M., Deng, Liyuan, Cosín-Tomás, Marta, Lu, Jessica, Malysheva, Olga, Leung, Kit-Yi, Ho, Ming-Kai, Pallàs, Mercè, Kaliman, Perla, Greene, Nicholas D.E., Bedell, Barry J., Caudill, Marie A., Rozen, Rima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409086/ https://www.ncbi.nlm.nih.gov/pubmed/28069796 http://dx.doi.org/10.1093/hmg/ddx004

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