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Evidence of epigenetic admixture in the Colombian population

DNA methylation (DNAm) measured in lymphoblastoid cell lines has been repeatedly demonstrated to differ between various human populations. Due to the role that DNAm plays in controlling gene expression, these differences could significantly contribute to ethnic phenotypic differences. However, becau...

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Autores principales: Rawlik, Konrad, Rowlatt, Amy, Sanabria-Salas, María Carolina, Hernández-Suárez, Gustavo, Serrano López, Martha Lucía, Zabaleta, Jovanny, Tenesa, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409088/
https://www.ncbi.nlm.nih.gov/pubmed/28073928
http://dx.doi.org/10.1093/hmg/ddw407
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author Rawlik, Konrad
Rowlatt, Amy
Sanabria-Salas, María Carolina
Hernández-Suárez, Gustavo
Serrano López, Martha Lucía
Zabaleta, Jovanny
Tenesa, Albert
author_facet Rawlik, Konrad
Rowlatt, Amy
Sanabria-Salas, María Carolina
Hernández-Suárez, Gustavo
Serrano López, Martha Lucía
Zabaleta, Jovanny
Tenesa, Albert
author_sort Rawlik, Konrad
collection PubMed
description DNA methylation (DNAm) measured in lymphoblastoid cell lines has been repeatedly demonstrated to differ between various human populations. Due to the role that DNAm plays in controlling gene expression, these differences could significantly contribute to ethnic phenotypic differences. However, because previous studies have compared distinct ethnic groups where genetic and environmental context are confounded, their relative contribution to phenotypic differences between ethnicities remains unclear. Using DNAm assayed in whole blood and colorectal tissue of 132 admixed individuals from Colombia, we identified sites where differential DNAm levels were associated with the local ancestral genetic context. Our results are consistent with population specific DNAm being primarily driven by between population genetic differences in cis, with little environmental contribution, and with consistent effects across tissues. The findings offer new insights into a possible mechanism driving phenotypic differences among different ethnic groups, and could help explain ethnic differences in colorectal cancer incidence.
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spelling pubmed-54090882017-05-03 Evidence of epigenetic admixture in the Colombian population Rawlik, Konrad Rowlatt, Amy Sanabria-Salas, María Carolina Hernández-Suárez, Gustavo Serrano López, Martha Lucía Zabaleta, Jovanny Tenesa, Albert Hum Mol Genet Articles DNA methylation (DNAm) measured in lymphoblastoid cell lines has been repeatedly demonstrated to differ between various human populations. Due to the role that DNAm plays in controlling gene expression, these differences could significantly contribute to ethnic phenotypic differences. However, because previous studies have compared distinct ethnic groups where genetic and environmental context are confounded, their relative contribution to phenotypic differences between ethnicities remains unclear. Using DNAm assayed in whole blood and colorectal tissue of 132 admixed individuals from Colombia, we identified sites where differential DNAm levels were associated with the local ancestral genetic context. Our results are consistent with population specific DNAm being primarily driven by between population genetic differences in cis, with little environmental contribution, and with consistent effects across tissues. The findings offer new insights into a possible mechanism driving phenotypic differences among different ethnic groups, and could help explain ethnic differences in colorectal cancer incidence. Oxford University Press 2017-02-01 2017-01-10 /pmc/articles/PMC5409088/ /pubmed/28073928 http://dx.doi.org/10.1093/hmg/ddw407 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Rawlik, Konrad
Rowlatt, Amy
Sanabria-Salas, María Carolina
Hernández-Suárez, Gustavo
Serrano López, Martha Lucía
Zabaleta, Jovanny
Tenesa, Albert
Evidence of epigenetic admixture in the Colombian population
title Evidence of epigenetic admixture in the Colombian population
title_full Evidence of epigenetic admixture in the Colombian population
title_fullStr Evidence of epigenetic admixture in the Colombian population
title_full_unstemmed Evidence of epigenetic admixture in the Colombian population
title_short Evidence of epigenetic admixture in the Colombian population
title_sort evidence of epigenetic admixture in the colombian population
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409088/
https://www.ncbi.nlm.nih.gov/pubmed/28073928
http://dx.doi.org/10.1093/hmg/ddw407
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