Cargando…

Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy mice

Spinal muscular atrophy (SMA) has long been solely considered a neurodegenerative disorder. However, recent work has highlighted defects in many other cell types that could contribute to disease aetiology. Interestingly, the immune system has never been extensively studied in SMA. Defects in lymphoi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deguise, Marc-Olivier, De Repentigny, Yves, McFall, Emily, Auclair, Nicole, Sad, Subash, Kothary, Rashmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409095/ https://www.ncbi.nlm.nih.gov/pubmed/28108555 http://dx.doi.org/10.1093/hmg/ddw434

Ejemplares similares

Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy
por: Boyer, Justin G., et al.
Publicado: (2014)

Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy
por: Deguise, Marc-Olivier, et al.
Publicado: (2016)

Metabolic Dysfunction in Spinal Muscular Atrophy
por: Deguise, Marc-Olivier, et al.
Publicado: (2021)

Effect of genetic background on the phenotype of the Smn(2B/-) mouse model of spinal muscular atrophy
por: Eshraghi, Mehdi, et al.
Publicado: (2016)

Low fat diets increase survival of a mouse model of spinal muscular atrophy
por: Deguise, Marc‐Olivier, et al.
Publicado: (2019)

Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy
por: Deguise, Marc-Olivier, et al.
Publicado: (2020)

Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
por: Meijboom, Katharina E., et al.
Publicado: (2022)

Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy
por: Boyer, Justin G, et al.
Publicado: (2013)

Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy
por: Nash, Leslie A., et al.
Publicado: (2017)

Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology
por: Bowerman, Melissa, et al.
Publicado: (2014)

New insights into SMA pathogenesis: immune dysfunction and neuroinflammation
por: Deguise, Marc‐Olivier, et al.
Publicado: (2017)

Impaired kidney structure and function in spinal muscular atrophy
por: Nery, Flávia C., et al.
Publicado: (2019)

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy
por: Sleigh, James N., et al.
Publicado: (2011)

Suppression of the necroptotic cell death pathways improves survival in Smn(2B/−) mice
por: Chehade, Lucia, et al.
Publicado: (2022)

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice
por: Walter, Lisa M., et al.
Publicado: (2018)

Abnormal fatty acid metabolism is a core component of spinal muscular atrophy
por: Deguise, Marc‐Olivier, et al.
Publicado: (2019)

The Smn-Independent Beneficial Effects of Trichostatin A on an Intermediate Mouse Model of Spinal Muscular Atrophy
por: Liu, Hong, et al.
Publicado: (2014)

Spinal muscular atrophy type III complicated by spinal superficial siderosis: a case report with molecular and neuropathological findings
por: Pringle, Catherine Elizabeth, et al.
Publicado: (2020)

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy
por: Bowerman, Melissa, et al.
Publicado: (2012)

Sm-like proteins in the pathogenesis of Spinal Muscular Atrophy
por: Achsel, Tilmann, et al.
Publicado: (2015)

miRNA in spinal muscular atrophy pathogenesis and therapy
por: Magri, Francesca, et al.
Publicado: (2017)

Base editing as a genetic treatment for spinal muscular atrophy
por: Alves, Christiano R. R., et al.
Publicado: (2023)

Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn(2b/-) mouse model of spinal muscular atrophy
por: Murray, Lyndsay M., et al.
Publicado: (2015)

Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy
por: López-Cortés, Andrés, et al.
Publicado: (2022)

Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy
por: Malik, Bilal, et al.
Publicado: (2019)

Spinal muscular atrophy
por: D'Amico, Adele, et al.
Publicado: (2011)

Whole‐blood dysregulation of actin‐cytoskeleton pathway in adult spinal muscular atrophy patients
por: Siranosian, Jennifer J., et al.
Publicado: (2020)

Nusinersen for spinal muscular atrophy
por: Wurster, Claudia D., et al.
Publicado: (2018)

Spinal Muscular Atrophy and Ependymoma
por: Albakr, Aishah, et al.
Publicado: (2017)

Risdiplam for spinal muscular atrophy
Publicado: (2022)

Motor Unit Abnormalities in Dystonia musculorum Mice
por: De Repentigny, Yves, et al.
Publicado: (2011)

The Proteolipid Protein Promoter Drives Expression outside of the Oligodendrocyte Lineage during Embryonic and Early Postnatal Development
por: Michalski, John-Paul, et al.
Publicado: (2011)

Modeling Spinal Muscular Atrophy in Drosophila
por: Chang, Howard Chia-Hao, et al.
Publicado: (2008)

Carrier screening for spinal muscular atrophy
por: Prior, Thomas W.
Publicado: (2008)

Androgens in spinal and bulbar muscular atrophy
Publicado: (2012)

Spinal Muscular Atrophy: The Treatment Approved
por: Tabet, Rabih, et al.
Publicado: (2017)

Advances in spinal muscular atrophy therapeutics
por: Parente, Valeria, et al.
Publicado: (2018)

Euglycemic Ketoacidosis in Spinal Muscular Atrophy
por: Stoimenis, Dimitrios, et al.
Publicado: (2019)

Update on Biomarkers in Spinal Muscular Atrophy
por: Pino, Megan G, et al.
Publicado: (2021)

Onasemnogene abeparvovec for spinal muscular atrophy
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u738da8q6qcu87trcro10mlhk3