Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.Htt(Q111/+) mouse model of Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease whose predominant neuropathological signature is the selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant protein (huntingtin) is found in virtually every cell so far stu...

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Detalles Bibliográficos
Autores principales: Coffey, Sydney R., Bragg, Robert M., Minnig, Shawn, Ament, Seth A., Cantle, Jeffrey P., Glickenhaus, Anne, Shelnut, Daniel, Carrillo, José M., Shuttleworth, Dominic D., Rodier, Julie-Anne, Noguchi, Kimihiro, Bennett, C. Frank, Price, Nathan D., Kordasiewicz, Holly B., Carroll, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409169/
https://www.ncbi.nlm.nih.gov/pubmed/28453524
http://dx.doi.org/10.1371/journal.pone.0175968

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