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Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes

Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4(+) resident memory T cells are still being defined. In this study we addressed this issue with a population of protective ski...

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Detalles Bibliográficos
Autores principales: Glennie, Nelson D., Volk, Susan W., Scott, Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409171/
https://www.ncbi.nlm.nih.gov/pubmed/28419151
http://dx.doi.org/10.1371/journal.ppat.1006349
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author Glennie, Nelson D.
Volk, Susan W.
Scott, Phillip
author_facet Glennie, Nelson D.
Volk, Susan W.
Scott, Phillip
author_sort Glennie, Nelson D.
collection PubMed
description Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4(+) resident memory T cells are still being defined. In this study we addressed this issue with a population of protective skin-resident, IFNγ-producing CD4(+) memory T cells generated following Leishmania major infection. We previously found that resident memory T cells recruit circulating effector T cells to enhance immunity. Here we show that resident memory CD4(+) T cells mediate the delayed-hypersensitivity response observed in immune mice and provide protection without circulating T cells. This protection occurs rapidly after challenge, and requires the recruitment and activation of inflammatory monocytes, which limit parasites by production of both reactive oxygen species and nitric oxide. Overall, these data highlight a novel role for tissue-resident memory cells in recruiting and activating inflammatory monocytes, and underscore the central role that skin-resident T cells play in immunity to cutaneous leishmaniasis.
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spelling pubmed-54091712017-05-14 Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes Glennie, Nelson D. Volk, Susan W. Scott, Phillip PLoS Pathog Research Article Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4(+) resident memory T cells are still being defined. In this study we addressed this issue with a population of protective skin-resident, IFNγ-producing CD4(+) memory T cells generated following Leishmania major infection. We previously found that resident memory T cells recruit circulating effector T cells to enhance immunity. Here we show that resident memory CD4(+) T cells mediate the delayed-hypersensitivity response observed in immune mice and provide protection without circulating T cells. This protection occurs rapidly after challenge, and requires the recruitment and activation of inflammatory monocytes, which limit parasites by production of both reactive oxygen species and nitric oxide. Overall, these data highlight a novel role for tissue-resident memory cells in recruiting and activating inflammatory monocytes, and underscore the central role that skin-resident T cells play in immunity to cutaneous leishmaniasis. Public Library of Science 2017-04-18 /pmc/articles/PMC5409171/ /pubmed/28419151 http://dx.doi.org/10.1371/journal.ppat.1006349 Text en © 2017 Glennie et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Glennie, Nelson D.
Volk, Susan W.
Scott, Phillip
Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes
title Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes
title_full Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes
title_fullStr Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes
title_full_unstemmed Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes
title_short Skin-resident CD4(+) T cells protect against Leishmania major by recruiting and activating inflammatory monocytes
title_sort skin-resident cd4(+) t cells protect against leishmania major by recruiting and activating inflammatory monocytes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409171/
https://www.ncbi.nlm.nih.gov/pubmed/28419151
http://dx.doi.org/10.1371/journal.ppat.1006349
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