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DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation

Under replete growth conditions, abundant nutrient uptake leads to the systemic activation of insulin/IGF-1 signalling (IIS) and the promotion of stem cell growth/proliferation. Activated IIS can stimulate the ERK/MAPK pathway, the activation of which also supports optimal stem cell proliferation in...

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Detalles Bibliográficos
Autores principales:	Narbonne, Patrick, Maddox, Paul S., Labbé, Jean-Claude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409174/ https://www.ncbi.nlm.nih.gov/pubmed/28410423 http://dx.doi.org/10.1371/journal.pgen.1006738

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