Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

Breakage of one strand of DNA is the most common form of DNA damage. Most damaged DNA termini require end-processing in preparation for ligation. The importance of this step is highlighted by the association of defects in the 3′-end processing enzyme tyrosyl DNA phosphodiesterase 1 (TDP1) and neurod...

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Detalles Bibliográficos
Autores principales: Chiang, Shih-Chieh, Meagher, Martin, Kassouf, Nick, Hafezparast, Majid, McKinnon, Peter J., Haywood, Rachel, El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409496/
https://www.ncbi.nlm.nih.gov/pubmed/28508041
http://dx.doi.org/10.1126/sciadv.1602506

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