A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes

The overwhelming amount of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. We developed a novel whole-body insertional mutagenesis screen in mice, designed for the discovery of Pten-cooperating tumor...

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Detalles Bibliográficos
Autores principales: de la Rosa, Jorge, Weber, Julia, Friedrich, Mathias Josef, Li, Yilong, Rad, Lena, Ponstingl, Hannes, Liang, Qi, de Quirós, Sandra Bernaldo, Noorani, Imran, Metzakopian, Emmanouil, Strong, Alexander, Li, Meng Amy, Astudillo, Aurora, Fernández-García, María Teresa, Fernández-García, María Soledad, Hoffman, Gary J., Fuente, Rocío, Vassiliou, George S., Rad, Roland, López-Otín, Carlos, Bradley, Allan, Cadiñanos, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409503/
https://www.ncbi.nlm.nih.gov/pubmed/28319090
http://dx.doi.org/10.1038/ng.3817

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