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Idiosyncratic recognition of UUG/UUA codons by modified nucleoside 5-taurinomethyluridine, τm(5)U present at ‘wobble’ position in anticodon loop of tRNA(Leu): A molecular modeling approach

Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm(5)U) at the ‘wobble’ 34(th) position in tRNA(Leu) causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm(5)U(34) specifically recognizes UUG and UUA codons. Structural conseque...

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Detalles Bibliográficos
Autores principales:	Kamble, Asmita S., Fandilolu, Prayagraj M., Sambhare, Susmit B., Sonawane, Kailas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409519/ https://www.ncbi.nlm.nih.gov/pubmed/28453549 http://dx.doi.org/10.1371/journal.pone.0176756

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