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Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study

Use of pesticides by households in rural Ghana is common for residential pest control, agricultural use, and for the reduction of vectors carrying disease. However, few data are available about exposure to pesticides among this population. Our objective was to quantify urinary concentrations of meta...

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Autores principales: Wylie, Blair J., Ae-Ngibise, Kenneth A., Boamah, Ellen A., Mujtaba, Mohammed, Messerlian, Carmen, Hauser, Russ, Coull, Brent, Calafat, Antonia M., Jack, Darby, Kinney, Patrick L., Whyatt, Robin, Owusu-Agyei, Seth, Asante, Kwaku P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409555/
https://www.ncbi.nlm.nih.gov/pubmed/28353657
http://dx.doi.org/10.3390/ijerph14040354
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author Wylie, Blair J.
Ae-Ngibise, Kenneth A.
Boamah, Ellen A.
Mujtaba, Mohammed
Messerlian, Carmen
Hauser, Russ
Coull, Brent
Calafat, Antonia M.
Jack, Darby
Kinney, Patrick L.
Whyatt, Robin
Owusu-Agyei, Seth
Asante, Kwaku P.
author_facet Wylie, Blair J.
Ae-Ngibise, Kenneth A.
Boamah, Ellen A.
Mujtaba, Mohammed
Messerlian, Carmen
Hauser, Russ
Coull, Brent
Calafat, Antonia M.
Jack, Darby
Kinney, Patrick L.
Whyatt, Robin
Owusu-Agyei, Seth
Asante, Kwaku P.
author_sort Wylie, Blair J.
collection PubMed
description Use of pesticides by households in rural Ghana is common for residential pest control, agricultural use, and for the reduction of vectors carrying disease. However, few data are available about exposure to pesticides among this population. Our objective was to quantify urinary concentrations of metabolites of organophosphate (OP), pyrethroid, and select herbicides during pregnancy, and to explore exposure determinants. In 2014, 17 pregnant women from rural Ghana were surveyed about household pesticide use and provided weekly first morning urine voids during three visits (n = 51 samples). A total of 90.1% (46/51) of samples had detectable OP metabolites [geometric mean, GM (95% CI): 3,5,6-trichloro-2-pyridinol 0.54 µg/L (0.36–0.81), para-nitrophenol 0.71 µg/L (0.51–1.00)], 75.5% (37/49) had detectable pyrethroid metabolites [GM: 3-phenoxybenzoic acid 0.23 µg/L (0.17, 0.32)], and 70.5% (36/51) had detectable 2,4-dichlorophenoxyacetic acid levels, a herbicide [GM: 0.46 µg/L (0.29–0.73)]. Concentrations of para-nitrophenol and 2,4-dichlorophenoxyacetic acid in Ghanaian pregnant women appear higher when compared to nonpregnant reproductive-aged women in a reference U.S. population. Larger studies are necessary to more fully explore predictors of exposure in this population.
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spelling pubmed-54095552017-05-03 Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study Wylie, Blair J. Ae-Ngibise, Kenneth A. Boamah, Ellen A. Mujtaba, Mohammed Messerlian, Carmen Hauser, Russ Coull, Brent Calafat, Antonia M. Jack, Darby Kinney, Patrick L. Whyatt, Robin Owusu-Agyei, Seth Asante, Kwaku P. Int J Environ Res Public Health Communication Use of pesticides by households in rural Ghana is common for residential pest control, agricultural use, and for the reduction of vectors carrying disease. However, few data are available about exposure to pesticides among this population. Our objective was to quantify urinary concentrations of metabolites of organophosphate (OP), pyrethroid, and select herbicides during pregnancy, and to explore exposure determinants. In 2014, 17 pregnant women from rural Ghana were surveyed about household pesticide use and provided weekly first morning urine voids during three visits (n = 51 samples). A total of 90.1% (46/51) of samples had detectable OP metabolites [geometric mean, GM (95% CI): 3,5,6-trichloro-2-pyridinol 0.54 µg/L (0.36–0.81), para-nitrophenol 0.71 µg/L (0.51–1.00)], 75.5% (37/49) had detectable pyrethroid metabolites [GM: 3-phenoxybenzoic acid 0.23 µg/L (0.17, 0.32)], and 70.5% (36/51) had detectable 2,4-dichlorophenoxyacetic acid levels, a herbicide [GM: 0.46 µg/L (0.29–0.73)]. Concentrations of para-nitrophenol and 2,4-dichlorophenoxyacetic acid in Ghanaian pregnant women appear higher when compared to nonpregnant reproductive-aged women in a reference U.S. population. Larger studies are necessary to more fully explore predictors of exposure in this population. MDPI 2017-03-29 2017-04 /pmc/articles/PMC5409555/ /pubmed/28353657 http://dx.doi.org/10.3390/ijerph14040354 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Wylie, Blair J.
Ae-Ngibise, Kenneth A.
Boamah, Ellen A.
Mujtaba, Mohammed
Messerlian, Carmen
Hauser, Russ
Coull, Brent
Calafat, Antonia M.
Jack, Darby
Kinney, Patrick L.
Whyatt, Robin
Owusu-Agyei, Seth
Asante, Kwaku P.
Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
title Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
title_full Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
title_fullStr Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
title_full_unstemmed Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
title_short Urinary Concentrations of Insecticide and Herbicide Metabolites among Pregnant Women in Rural Ghana: A Pilot Study
title_sort urinary concentrations of insecticide and herbicide metabolites among pregnant women in rural ghana: a pilot study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409555/
https://www.ncbi.nlm.nih.gov/pubmed/28353657
http://dx.doi.org/10.3390/ijerph14040354
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