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Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand
To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marke...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409602/ https://www.ncbi.nlm.nih.gov/pubmed/28394292 http://dx.doi.org/10.3390/ijerph14040401 |
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author | Nishijo, Muneko Nambunmee, Kowit Suvagandha, Dhitiwass Swaddiwudhipong, Witaya Ruangyuttikarn, Werawan Nishino, Yoshikazu |
author_facet | Nishijo, Muneko Nambunmee, Kowit Suvagandha, Dhitiwass Swaddiwudhipong, Witaya Ruangyuttikarn, Werawan Nishino, Yoshikazu |
author_sort | Nishijo, Muneko |
collection | PubMed |
description | To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ≥ 10 μg/L or urinary cadmium ≥ 10 μg/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium. |
format | Online Article Text |
id | pubmed-5409602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54096022017-05-03 Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand Nishijo, Muneko Nambunmee, Kowit Suvagandha, Dhitiwass Swaddiwudhipong, Witaya Ruangyuttikarn, Werawan Nishino, Yoshikazu Int J Environ Res Public Health Article To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ≥ 10 μg/L or urinary cadmium ≥ 10 μg/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium. MDPI 2017-04-10 2017-04 /pmc/articles/PMC5409602/ /pubmed/28394292 http://dx.doi.org/10.3390/ijerph14040401 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nishijo, Muneko Nambunmee, Kowit Suvagandha, Dhitiwass Swaddiwudhipong, Witaya Ruangyuttikarn, Werawan Nishino, Yoshikazu Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand |
title | Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand |
title_full | Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand |
title_fullStr | Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand |
title_full_unstemmed | Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand |
title_short | Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand |
title_sort | gender-specific impact of cadmium exposure on bone metabolism in older people living in a cadmium-polluted area in thailand |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409602/ https://www.ncbi.nlm.nih.gov/pubmed/28394292 http://dx.doi.org/10.3390/ijerph14040401 |
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