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Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk

Choline is essential for infant development. Human milk choline is predominately present in three water-soluble choline (WSC) forms: free choline (FC), phosphocholine (PhosC), and glycerophosphocholine (GPC). It is unclear whether mother’s own preterm milk and pooled donor milk differ in WSC composi...

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Autores principales: Moukarzel, Sara, Soberanes, Lynda, Dyer, Roger A., Albersheim, Susan, Elango, Rajavel, Innis, Sheila M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409708/
https://www.ncbi.nlm.nih.gov/pubmed/28387717
http://dx.doi.org/10.3390/nu9040369
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author Moukarzel, Sara
Soberanes, Lynda
Dyer, Roger A.
Albersheim, Susan
Elango, Rajavel
Innis, Sheila M.
author_facet Moukarzel, Sara
Soberanes, Lynda
Dyer, Roger A.
Albersheim, Susan
Elango, Rajavel
Innis, Sheila M.
author_sort Moukarzel, Sara
collection PubMed
description Choline is essential for infant development. Human milk choline is predominately present in three water-soluble choline (WSC) forms: free choline (FC), phosphocholine (PhosC), and glycerophosphocholine (GPC). It is unclear whether mother’s own preterm milk and pooled donor milk differ in WSC composition and whether WSC compounds are interrelated. Mother’s own preterm milk (n = 75) and donor milk (n = 30) samples from the neonatal intensive care unit, BC Women’s Hospital were analyzed for WSC composition using liquid chromatography tandem mass spectrometry (LC-MS/MS). Associations between different WSC compounds were determined using Pearson’s correlations, followed by Fischer r-to-z transformation. Total WSC concentration and concentrations of FC, PhosC, and GPC did not significantly differ between mother’s own milk and donor milk. FC was negatively associated with PhosC and GPC in mother’s own milk (r = −0.27, p = 0.02; r = −0.34, p = 0.003, respectively), but not in donor milk (r = 0.26, p = 0.181 r = 0.37, p = 0.062, respectively). The difference in these associations between the two milk groups were statistically significant (p = 0.03 for the association between PhosC and FC; and p = 0.003 for the association between FC and GPC). PhosC and GPC were positively associated in mother’s own milk (r = 0.32, p = 0.036) but not donor milk (r = 0.36, p = 0.062), although the difference in correlation was not statistically significant. The metabolic and clinical implications of these associations on the preterm infant need to be further elucidated.
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spelling pubmed-54097082017-05-03 Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk Moukarzel, Sara Soberanes, Lynda Dyer, Roger A. Albersheim, Susan Elango, Rajavel Innis, Sheila M. Nutrients Article Choline is essential for infant development. Human milk choline is predominately present in three water-soluble choline (WSC) forms: free choline (FC), phosphocholine (PhosC), and glycerophosphocholine (GPC). It is unclear whether mother’s own preterm milk and pooled donor milk differ in WSC composition and whether WSC compounds are interrelated. Mother’s own preterm milk (n = 75) and donor milk (n = 30) samples from the neonatal intensive care unit, BC Women’s Hospital were analyzed for WSC composition using liquid chromatography tandem mass spectrometry (LC-MS/MS). Associations between different WSC compounds were determined using Pearson’s correlations, followed by Fischer r-to-z transformation. Total WSC concentration and concentrations of FC, PhosC, and GPC did not significantly differ between mother’s own milk and donor milk. FC was negatively associated with PhosC and GPC in mother’s own milk (r = −0.27, p = 0.02; r = −0.34, p = 0.003, respectively), but not in donor milk (r = 0.26, p = 0.181 r = 0.37, p = 0.062, respectively). The difference in these associations between the two milk groups were statistically significant (p = 0.03 for the association between PhosC and FC; and p = 0.003 for the association between FC and GPC). PhosC and GPC were positively associated in mother’s own milk (r = 0.32, p = 0.036) but not donor milk (r = 0.36, p = 0.062), although the difference in correlation was not statistically significant. The metabolic and clinical implications of these associations on the preterm infant need to be further elucidated. MDPI 2017-04-07 /pmc/articles/PMC5409708/ /pubmed/28387717 http://dx.doi.org/10.3390/nu9040369 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moukarzel, Sara
Soberanes, Lynda
Dyer, Roger A.
Albersheim, Susan
Elango, Rajavel
Innis, Sheila M.
Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk
title Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk
title_full Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk
title_fullStr Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk
title_full_unstemmed Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk
title_short Relationships among Different Water-Soluble Choline Compounds Differ between Human Preterm and Donor Milk
title_sort relationships among different water-soluble choline compounds differ between human preterm and donor milk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409708/
https://www.ncbi.nlm.nih.gov/pubmed/28387717
http://dx.doi.org/10.3390/nu9040369
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