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Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report

A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabo...

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Autores principales: Tran, Nhat-Thang, Alexandre-Gouabau, Marie-Cécile, Pagniez, Anthony, Ouguerram, Khadija, Boquien, Clair-Yves, Winer, Norbert, Darmaun, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409714/
https://www.ncbi.nlm.nih.gov/pubmed/28398243
http://dx.doi.org/10.3390/nu9040375
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author Tran, Nhat-Thang
Alexandre-Gouabau, Marie-Cécile
Pagniez, Anthony
Ouguerram, Khadija
Boquien, Clair-Yves
Winer, Norbert
Darmaun, Dominique
author_facet Tran, Nhat-Thang
Alexandre-Gouabau, Marie-Cécile
Pagniez, Anthony
Ouguerram, Khadija
Boquien, Clair-Yves
Winer, Norbert
Darmaun, Dominique
author_sort Tran, Nhat-Thang
collection PubMed
description A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet.
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spelling pubmed-54097142017-05-03 Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report Tran, Nhat-Thang Alexandre-Gouabau, Marie-Cécile Pagniez, Anthony Ouguerram, Khadija Boquien, Clair-Yves Winer, Norbert Darmaun, Dominique Nutrients Communication A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet. MDPI 2017-04-11 /pmc/articles/PMC5409714/ /pubmed/28398243 http://dx.doi.org/10.3390/nu9040375 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Tran, Nhat-Thang
Alexandre-Gouabau, Marie-Cécile
Pagniez, Anthony
Ouguerram, Khadija
Boquien, Clair-Yves
Winer, Norbert
Darmaun, Dominique
Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
title Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
title_full Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
title_fullStr Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
title_full_unstemmed Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
title_short Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report
title_sort neonatal citrulline supplementation and later exposure to a high fructose diet in rats born with a low birth weight: a preliminary report
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409714/
https://www.ncbi.nlm.nih.gov/pubmed/28398243
http://dx.doi.org/10.3390/nu9040375
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