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Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies

Epidemiological studies have shown inconsistent findings on the association between chocolate consumption and risk of heart failure (HF). We, therefore, performed a meta-analysis of prospective studies to determine the role of chocolate intake in the prevention of HF. We searched databases of PubMed...

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Autores principales: Gong, Fei, Yao, Shuyuan, Wan, Jing, Gan, Xuedong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409741/
https://www.ncbi.nlm.nih.gov/pubmed/28425931
http://dx.doi.org/10.3390/nu9040402
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author Gong, Fei
Yao, Shuyuan
Wan, Jing
Gan, Xuedong
author_facet Gong, Fei
Yao, Shuyuan
Wan, Jing
Gan, Xuedong
author_sort Gong, Fei
collection PubMed
description Epidemiological studies have shown inconsistent findings on the association between chocolate consumption and risk of heart failure (HF). We, therefore, performed a meta-analysis of prospective studies to determine the role of chocolate intake in the prevention of HF. We searched databases of PubMed, Web of Science, and Scopus through December 2016 and scrutinized the reference lists of relevant literatures to identify eligible studies. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were aggregated using random effect models. The dose–response relationship between chocolate consumption and incident HF was also assessed. This meta-analysis is registered with PROSPERO, number CRD42017054230. Five prospective studies with 106,109 participants were finally included. Compared to no consumption of chocolate, the pooled HRs (95% CIs) of HF were 0.86 (0.82–0.91) for low-to-moderate consumption (<7 servings/week) and 0.94 (0.80–1.09) for high consumption (≥7 servings/week). In dose–response meta-analysis, we detected a curve linear relationship between chocolate consumption and risk of HF (p for nonlinearity = 0.005). Compared with non-consumption, the HRs (95% CIs) of HF across chocolate consumption levels were 0.92 (0.88–0.97), 0.86 (0.78–0.94), 0.93 (0.85–1.03), and 1.07 (0.92–1.23) for 1, 3, 7, and 10 servings/week, respectively. In conclusion, chocolate consumption in moderation may be associated with a decreased risk of HF.
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spelling pubmed-54097412017-05-03 Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies Gong, Fei Yao, Shuyuan Wan, Jing Gan, Xuedong Nutrients Article Epidemiological studies have shown inconsistent findings on the association between chocolate consumption and risk of heart failure (HF). We, therefore, performed a meta-analysis of prospective studies to determine the role of chocolate intake in the prevention of HF. We searched databases of PubMed, Web of Science, and Scopus through December 2016 and scrutinized the reference lists of relevant literatures to identify eligible studies. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were aggregated using random effect models. The dose–response relationship between chocolate consumption and incident HF was also assessed. This meta-analysis is registered with PROSPERO, number CRD42017054230. Five prospective studies with 106,109 participants were finally included. Compared to no consumption of chocolate, the pooled HRs (95% CIs) of HF were 0.86 (0.82–0.91) for low-to-moderate consumption (<7 servings/week) and 0.94 (0.80–1.09) for high consumption (≥7 servings/week). In dose–response meta-analysis, we detected a curve linear relationship between chocolate consumption and risk of HF (p for nonlinearity = 0.005). Compared with non-consumption, the HRs (95% CIs) of HF across chocolate consumption levels were 0.92 (0.88–0.97), 0.86 (0.78–0.94), 0.93 (0.85–1.03), and 1.07 (0.92–1.23) for 1, 3, 7, and 10 servings/week, respectively. In conclusion, chocolate consumption in moderation may be associated with a decreased risk of HF. MDPI 2017-04-20 /pmc/articles/PMC5409741/ /pubmed/28425931 http://dx.doi.org/10.3390/nu9040402 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gong, Fei
Yao, Shuyuan
Wan, Jing
Gan, Xuedong
Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies
title Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies
title_full Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies
title_fullStr Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies
title_full_unstemmed Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies
title_short Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies
title_sort chocolate consumption and risk of heart failure: a meta-analysis of prospective studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409741/
https://www.ncbi.nlm.nih.gov/pubmed/28425931
http://dx.doi.org/10.3390/nu9040402
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