Cargando…

FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance

The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates. Intrinsically disorder protein regions (IDRs) are protein segments that exhibit multiple physical interactions and play crit...

Descripción completa

Detalles Bibliográficos
Autores principales: Viscardi, Lucas Henriques, Tovo-Rodrigues, Luciana, Paré, Pamela, Fagundes, Nelson Jurandi Rosa, Salzano, Francisco Mauro, Paixão-Côrtes, Vanessa Rodrigues, Bau, Claiton Henrique Dotto, Bortolini, Maria Cátira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409772/
https://www.ncbi.nlm.nih.gov/pubmed/28257525
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0115
_version_ 1783232545166458880
author Viscardi, Lucas Henriques
Tovo-Rodrigues, Luciana
Paré, Pamela
Fagundes, Nelson Jurandi Rosa
Salzano, Francisco Mauro
Paixão-Côrtes, Vanessa Rodrigues
Bau, Claiton Henrique Dotto
Bortolini, Maria Cátira
author_facet Viscardi, Lucas Henriques
Tovo-Rodrigues, Luciana
Paré, Pamela
Fagundes, Nelson Jurandi Rosa
Salzano, Francisco Mauro
Paixão-Côrtes, Vanessa Rodrigues
Bau, Claiton Henrique Dotto
Bortolini, Maria Cátira
author_sort Viscardi, Lucas Henriques
collection PubMed
description The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates. Intrinsically disorder protein regions (IDRs) are protein segments that exhibit multiple physical interactions and play critical roles in various biological processes, including regulation and signaling. IDRs in proteins may play an important role in the evolvability of genetic systems. In this study, we analyzed 77 orthologous FOXP genes/proteins from Tetrapoda, regarding protein disorder content and evolutionary rate. We also predicted the number and type of short linear motifs (SLIMs) in the IDRs. Similar levels of protein disorder (approximately 70%) were found for FOXP1, FOXP2, and FOXP4. However, for FOXP3, which is shorter in length and has a more specific function, the disordered content was lower (30%). Mammals showed higher protein disorders for FOXP1 and FOXP4 than non-mammals. Specific analyses related to linear motifs in the four genes showed also a clear differentiation between FOXPs in mammals and non-mammals. We predicted for the first time the role of IDRs and SLIMs in the FOXP gene family associated with possible adaptive novelties within Tetrapoda. For instance, we found gain and loss of important phosphorylation sites in the Homo sapiens FOXP2 IDR regions, with possible implication for the evolution of human speech.
format Online
Article
Text
id pubmed-5409772
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Sociedade Brasileira de Genética
record_format MEDLINE/PubMed
spelling pubmed-54097722017-05-08 FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance Viscardi, Lucas Henriques Tovo-Rodrigues, Luciana Paré, Pamela Fagundes, Nelson Jurandi Rosa Salzano, Francisco Mauro Paixão-Côrtes, Vanessa Rodrigues Bau, Claiton Henrique Dotto Bortolini, Maria Cátira Genet Mol Biol Genomics and Bioinformatics The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates. Intrinsically disorder protein regions (IDRs) are protein segments that exhibit multiple physical interactions and play critical roles in various biological processes, including regulation and signaling. IDRs in proteins may play an important role in the evolvability of genetic systems. In this study, we analyzed 77 orthologous FOXP genes/proteins from Tetrapoda, regarding protein disorder content and evolutionary rate. We also predicted the number and type of short linear motifs (SLIMs) in the IDRs. Similar levels of protein disorder (approximately 70%) were found for FOXP1, FOXP2, and FOXP4. However, for FOXP3, which is shorter in length and has a more specific function, the disordered content was lower (30%). Mammals showed higher protein disorders for FOXP1 and FOXP4 than non-mammals. Specific analyses related to linear motifs in the four genes showed also a clear differentiation between FOXPs in mammals and non-mammals. We predicted for the first time the role of IDRs and SLIMs in the FOXP gene family associated with possible adaptive novelties within Tetrapoda. For instance, we found gain and loss of important phosphorylation sites in the Homo sapiens FOXP2 IDR regions, with possible implication for the evolution of human speech. Sociedade Brasileira de Genética 2017-03-02 2017 /pmc/articles/PMC5409772/ /pubmed/28257525 http://dx.doi.org/10.1590/1678-4685-GMB-2016-0115 Text en Copyright © 2017, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Genomics and Bioinformatics
Viscardi, Lucas Henriques
Tovo-Rodrigues, Luciana
Paré, Pamela
Fagundes, Nelson Jurandi Rosa
Salzano, Francisco Mauro
Paixão-Côrtes, Vanessa Rodrigues
Bau, Claiton Henrique Dotto
Bortolini, Maria Cátira
FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
title FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
title_full FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
title_fullStr FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
title_full_unstemmed FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
title_short FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance
title_sort foxp in tetrapoda: intrinsically disordered regions, short linear motifs and their evolutionary significance
topic Genomics and Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409772/
https://www.ncbi.nlm.nih.gov/pubmed/28257525
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0115
work_keys_str_mv AT viscardilucashenriques foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT tovorodriguesluciana foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT parepamela foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT fagundesnelsonjurandirosa foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT salzanofranciscomauro foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT paixaocortesvanessarodrigues foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT bauclaitonhenriquedotto foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance
AT bortolinimariacatira foxpintetrapodaintrinsicallydisorderedregionsshortlinearmotifsandtheirevolutionarysignificance