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Paternal Age Alters Social Development in Offspring
OBJECTIVE: Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population. METHOD: We used multil...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409803/ https://www.ncbi.nlm.nih.gov/pubmed/28433087 http://dx.doi.org/10.1016/j.jaac.2017.02.006 |
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author | Janecka, Magdalena Haworth, Claire M.A. Ronald, Angelica Krapohl, Eva Happé, Francesca Mill, Jonathan Schalkwyk, Leonard C. Fernandes, Cathy Reichenberg, Abraham Rijsdijk, Frühling |
author_facet | Janecka, Magdalena Haworth, Claire M.A. Ronald, Angelica Krapohl, Eva Happé, Francesca Mill, Jonathan Schalkwyk, Leonard C. Fernandes, Cathy Reichenberg, Abraham Rijsdijk, Frühling |
author_sort | Janecka, Magdalena |
collection | PubMed |
description | OBJECTIVE: Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population. METHOD: We used multilevel growth modeling to investigate APA effects on socioemotional development from early childhood until adolescence, as measured by the Strengths and Difficulties Questionnaire (SDQ) in the Twins Early Development Study (TEDS) sample. We also investigated genetic and environmental underpinnings of the paternal age effects on development, using the Additive genetics, Common environment, unique Environment (ACE) and gene–environment (GxE) models. RESULTS: In the general population, both very young and advanced paternal ages were associated with altered trajectory of social development (intercept: p = .01; slope: p = .03). No other behavioral domain was affected by either young or advanced age at fatherhood, suggesting specificity of paternal age effects. Increased importance of genetic factors in social development was recorded in the offspring of older but not very young fathers, suggesting distinct underpinnings of the paternal age effects at these two extremes. CONCLUSION: Our findings highlight that the APA-related deficits that lead to autism and schizophrenia are likely continuously distributed in the population. |
format | Online Article Text |
id | pubmed-5409803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54098032017-05-05 Paternal Age Alters Social Development in Offspring Janecka, Magdalena Haworth, Claire M.A. Ronald, Angelica Krapohl, Eva Happé, Francesca Mill, Jonathan Schalkwyk, Leonard C. Fernandes, Cathy Reichenberg, Abraham Rijsdijk, Frühling J Am Acad Child Adolesc Psychiatry New Research OBJECTIVE: Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population. METHOD: We used multilevel growth modeling to investigate APA effects on socioemotional development from early childhood until adolescence, as measured by the Strengths and Difficulties Questionnaire (SDQ) in the Twins Early Development Study (TEDS) sample. We also investigated genetic and environmental underpinnings of the paternal age effects on development, using the Additive genetics, Common environment, unique Environment (ACE) and gene–environment (GxE) models. RESULTS: In the general population, both very young and advanced paternal ages were associated with altered trajectory of social development (intercept: p = .01; slope: p = .03). No other behavioral domain was affected by either young or advanced age at fatherhood, suggesting specificity of paternal age effects. Increased importance of genetic factors in social development was recorded in the offspring of older but not very young fathers, suggesting distinct underpinnings of the paternal age effects at these two extremes. CONCLUSION: Our findings highlight that the APA-related deficits that lead to autism and schizophrenia are likely continuously distributed in the population. Elsevier 2017-05 /pmc/articles/PMC5409803/ /pubmed/28433087 http://dx.doi.org/10.1016/j.jaac.2017.02.006 Text en © 2017 The Authors. American Academy of Child and Adolescent Psychiatry. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | New Research Janecka, Magdalena Haworth, Claire M.A. Ronald, Angelica Krapohl, Eva Happé, Francesca Mill, Jonathan Schalkwyk, Leonard C. Fernandes, Cathy Reichenberg, Abraham Rijsdijk, Frühling Paternal Age Alters Social Development in Offspring |
title | Paternal Age Alters Social Development in Offspring |
title_full | Paternal Age Alters Social Development in Offspring |
title_fullStr | Paternal Age Alters Social Development in Offspring |
title_full_unstemmed | Paternal Age Alters Social Development in Offspring |
title_short | Paternal Age Alters Social Development in Offspring |
title_sort | paternal age alters social development in offspring |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409803/ https://www.ncbi.nlm.nih.gov/pubmed/28433087 http://dx.doi.org/10.1016/j.jaac.2017.02.006 |
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