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Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis

Osteopetrosis (OP) comprehends a rare group of conditions, presenting on radiographs increased bone density, deriving from irregularities in osteoclast differentiation or function. In the autosomal dominant osteopetrosis (ADO), some patients stay asymptomatic for some time, or only develop mild symp...

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Autores principales: da Silva Barbirato, Davi, Fogacci, Mariana Fampa, Arruda, Mariana, Rodrigues, Monique Oliveira, Neto, Leonardo Vieira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409937/
https://www.ncbi.nlm.nih.gov/pubmed/28469925
http://dx.doi.org/10.1530/EDM-16-0106
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author da Silva Barbirato, Davi
Fogacci, Mariana Fampa
Arruda, Mariana
Rodrigues, Monique Oliveira
Neto, Leonardo Vieira
author_facet da Silva Barbirato, Davi
Fogacci, Mariana Fampa
Arruda, Mariana
Rodrigues, Monique Oliveira
Neto, Leonardo Vieira
author_sort da Silva Barbirato, Davi
collection PubMed
description Osteopetrosis (OP) comprehends a rare group of conditions, presenting on radiographs increased bone density, deriving from irregularities in osteoclast differentiation or function. In the autosomal dominant osteopetrosis (ADO), some patients stay asymptomatic for some time, or only develop mild symptoms. The dental surgeon is often the first to presuppose the disease during routine imaging examinations, referring the patient to a specialized medical group. Furthermore, osteomyelitis is one of the major OP complications, and should be refrained through frequent dental monitoring. Signals of cortical interruption, sclerotic sequestra or periosteal new bone formation, should be looked for in these patients. Their dental management is complex and procedures encompassing bone tissue, such as implant procedures, tissue regenerations, tooth extractions, maxillofacial surgeries and orthodontic treatments, when elected, should be avoided. This case report describes a case of ADO with a diagnosis of moderate generalized chronic periodontitis, not statistically related to plaque index. This is the first case to describe such a condition, in which the systemic component and the altered bone metabolism seem to be related to the loss of periodontal apparatus, independent of the biofilm. Concerning prevention, we can reinforce the need for frequent dental monitoring to avoid further interventions in those cases. LEARNING POINTS: This paper reports a case in which the systemic component and the altered bone metabolism seem to have been related to the loss of periodontal attachment apparatus, independent of the biofilm. The periodontal damage observed in the OP patient was not related to the dental plaque, which leads us to suggest that the cases of periodontitis in OP patients should be diagnosed as periodontitis as a manifestation of systemic diseases. The periodontitis prevention should be longed for in OP patients thus, we propose that doctors responsible for patients with OP refer them to a dental service as soon as possible and that dentists should be aware of the preventive dentistry value as well as the most appropriate dental management for those cases.
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spelling pubmed-54099372017-05-03 Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis da Silva Barbirato, Davi Fogacci, Mariana Fampa Arruda, Mariana Rodrigues, Monique Oliveira Neto, Leonardo Vieira Endocrinol Diabetes Metab Case Rep Insight into Disease Pathogenesis or Mechanism of Therapy Osteopetrosis (OP) comprehends a rare group of conditions, presenting on radiographs increased bone density, deriving from irregularities in osteoclast differentiation or function. In the autosomal dominant osteopetrosis (ADO), some patients stay asymptomatic for some time, or only develop mild symptoms. The dental surgeon is often the first to presuppose the disease during routine imaging examinations, referring the patient to a specialized medical group. Furthermore, osteomyelitis is one of the major OP complications, and should be refrained through frequent dental monitoring. Signals of cortical interruption, sclerotic sequestra or periosteal new bone formation, should be looked for in these patients. Their dental management is complex and procedures encompassing bone tissue, such as implant procedures, tissue regenerations, tooth extractions, maxillofacial surgeries and orthodontic treatments, when elected, should be avoided. This case report describes a case of ADO with a diagnosis of moderate generalized chronic periodontitis, not statistically related to plaque index. This is the first case to describe such a condition, in which the systemic component and the altered bone metabolism seem to be related to the loss of periodontal apparatus, independent of the biofilm. Concerning prevention, we can reinforce the need for frequent dental monitoring to avoid further interventions in those cases. LEARNING POINTS: This paper reports a case in which the systemic component and the altered bone metabolism seem to have been related to the loss of periodontal attachment apparatus, independent of the biofilm. The periodontal damage observed in the OP patient was not related to the dental plaque, which leads us to suggest that the cases of periodontitis in OP patients should be diagnosed as periodontitis as a manifestation of systemic diseases. The periodontitis prevention should be longed for in OP patients thus, we propose that doctors responsible for patients with OP refer them to a dental service as soon as possible and that dentists should be aware of the preventive dentistry value as well as the most appropriate dental management for those cases. Bioscientifica Ltd 2017-04-21 /pmc/articles/PMC5409937/ /pubmed/28469925 http://dx.doi.org/10.1530/EDM-16-0106 Text en © 2017 The authors http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en_GB This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en_GB) .
spellingShingle Insight into Disease Pathogenesis or Mechanism of Therapy
da Silva Barbirato, Davi
Fogacci, Mariana Fampa
Arruda, Mariana
Rodrigues, Monique Oliveira
Neto, Leonardo Vieira
Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
title Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
title_full Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
title_fullStr Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
title_full_unstemmed Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
title_short Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
title_sort periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis
topic Insight into Disease Pathogenesis or Mechanism of Therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409937/
https://www.ncbi.nlm.nih.gov/pubmed/28469925
http://dx.doi.org/10.1530/EDM-16-0106
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