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Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD. Methods: We recruited 60 patients with CHD and 30 healthy children, from 2...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences, 2006-
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409944/ https://www.ncbi.nlm.nih.gov/pubmed/28469687 |
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author | Noori, Noor Mohammand Shahramian, Iraj Teimouri, Alireza Keyvani, Behrooz Mahjoubifard, Maziar |
author_facet | Noori, Noor Mohammand Shahramian, Iraj Teimouri, Alireza Keyvani, Behrooz Mahjoubifard, Maziar |
author_sort | Noori, Noor Mohammand |
collection | PubMed |
description | Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD. Methods: We recruited 60 patients with CHD and 30 healthy children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants’ demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-18 were measured via ELISA. Results: Mean age of the participants was 4.28 ± 3.44, 3.12 ± 3.87, and 3.30 ± 3.61 years in the cyanotic, acyanotic, and control groups, respectively (p value = 0.414). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), IL-18 (p value = 0.030), right ventricular pressure (p value < 0.001), and pulmonary pressure (p value = 0.015) were higher in the case group, while the BMI was higher in the controls (p value < 0.001). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), and right ventricular pressure (p value < 0.001) were significantly higher in the cyanotic children, whereas the BMI was higher in the controls (p value < 0.001). Levels of TNF-α and IL-6 had significant correlations with right ventricular pressure. Conclusion: The present study showed a differed serum cytokines levels between children with and without CHD. |
format | Online Article Text |
id | pubmed-5409944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Tehran University of Medical Sciences, 2006- |
record_format | MEDLINE/PubMed |
spelling | pubmed-54099442017-05-03 Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease Noori, Noor Mohammand Shahramian, Iraj Teimouri, Alireza Keyvani, Behrooz Mahjoubifard, Maziar J Tehran Heart Cent Original Article Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD. Methods: We recruited 60 patients with CHD and 30 healthy children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants’ demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-18 were measured via ELISA. Results: Mean age of the participants was 4.28 ± 3.44, 3.12 ± 3.87, and 3.30 ± 3.61 years in the cyanotic, acyanotic, and control groups, respectively (p value = 0.414). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), IL-18 (p value = 0.030), right ventricular pressure (p value < 0.001), and pulmonary pressure (p value = 0.015) were higher in the case group, while the BMI was higher in the controls (p value < 0.001). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), and right ventricular pressure (p value < 0.001) were significantly higher in the cyanotic children, whereas the BMI was higher in the controls (p value < 0.001). Levels of TNF-α and IL-6 had significant correlations with right ventricular pressure. Conclusion: The present study showed a differed serum cytokines levels between children with and without CHD. Tehran University of Medical Sciences, 2006- 2017-01 /pmc/articles/PMC5409944/ /pubmed/28469687 Text en Copyright © 2015 Tehran Heart Center, Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Noori, Noor Mohammand Shahramian, Iraj Teimouri, Alireza Keyvani, Behrooz Mahjoubifard, Maziar Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease |
title | Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease |
title_full | Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease |
title_fullStr | Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease |
title_full_unstemmed | Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease |
title_short | Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease |
title_sort | serum levels of tumor necrosis factor-α and interleukins in children with congenital heart disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409944/ https://www.ncbi.nlm.nih.gov/pubmed/28469687 |
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