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Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease

Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD.  Methods: We recruited 60 patients with CHD and 30 healthy children, from 2...

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Detalles Bibliográficos
Autores principales: Noori, Noor Mohammand, Shahramian, Iraj, Teimouri, Alireza, Keyvani, Behrooz, Mahjoubifard, Maziar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, 2006- 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409944/
https://www.ncbi.nlm.nih.gov/pubmed/28469687
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author Noori, Noor Mohammand
Shahramian, Iraj
Teimouri, Alireza
Keyvani, Behrooz
Mahjoubifard, Maziar
author_facet Noori, Noor Mohammand
Shahramian, Iraj
Teimouri, Alireza
Keyvani, Behrooz
Mahjoubifard, Maziar
author_sort Noori, Noor Mohammand
collection PubMed
description Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD.  Methods: We recruited 60 patients with CHD and 30 healthy children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants’ demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-18 were measured via ELISA. Results: Mean age of the participants was 4.28 ± 3.44, 3.12 ± 3.87, and 3.30 ± 3.61 years in the cyanotic, acyanotic, and control groups, respectively (p value = 0.414). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), IL-18 (p value = 0.030), right ventricular pressure (p value < 0.001), and pulmonary pressure (p value = 0.015) were higher in the case group, while the BMI was higher in the controls (p value < 0.001). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), and right ventricular pressure (p value < 0.001) were significantly higher in the cyanotic children, whereas the BMI was higher in the controls (p value < 0.001). Levels of TNF-α and IL-6 had significant correlations with right ventricular pressure.   Conclusion: The present study showed a differed serum cytokines levels between children with and without CHD.
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spelling pubmed-54099442017-05-03 Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease Noori, Noor Mohammand Shahramian, Iraj Teimouri, Alireza Keyvani, Behrooz Mahjoubifard, Maziar J Tehran Heart Cent Original Article Background: Levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (CHD). We sought to assess the difference in serum cytokines levels between children with and without CHD.  Methods: We recruited 60 patients with CHD and 30 healthy children, from 2013 to 2014. Patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine, and chronic inflammatory diseases; fever; infection in the preceding 3 weeks; and malnutrition were excluded. Participants’ demographic data were measured, and their cardiac diseases were diagnosed via echocardiography. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-18 were measured via ELISA. Results: Mean age of the participants was 4.28 ± 3.44, 3.12 ± 3.87, and 3.30 ± 3.61 years in the cyanotic, acyanotic, and control groups, respectively (p value = 0.414). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), IL-18 (p value = 0.030), right ventricular pressure (p value < 0.001), and pulmonary pressure (p value = 0.015) were higher in the case group, while the BMI was higher in the controls (p value < 0.001). Mean values of TNF-α (p value < 0.001), IL-6 (p value < 0.001), and right ventricular pressure (p value < 0.001) were significantly higher in the cyanotic children, whereas the BMI was higher in the controls (p value < 0.001). Levels of TNF-α and IL-6 had significant correlations with right ventricular pressure.   Conclusion: The present study showed a differed serum cytokines levels between children with and without CHD. Tehran University of Medical Sciences, 2006- 2017-01 /pmc/articles/PMC5409944/ /pubmed/28469687 Text en Copyright © 2015 Tehran Heart Center, Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Noori, Noor Mohammand
Shahramian, Iraj
Teimouri, Alireza
Keyvani, Behrooz
Mahjoubifard, Maziar
Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
title Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
title_full Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
title_fullStr Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
title_full_unstemmed Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
title_short Serum Levels of Tumor Necrosis Factor-α and Interleukins in Children with Congenital Heart Disease
title_sort serum levels of tumor necrosis factor-α and interleukins in children with congenital heart disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409944/
https://www.ncbi.nlm.nih.gov/pubmed/28469687
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