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Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons

Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson’s disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria and impair respiration, while reduced αsyn pr...

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Detalles Bibliográficos
Autores principales:	Pathak, Divya, Berthet, Amandine, Bendor, Jacob T., Yu, Katharine, Sellnow, Rhyomi C., Orr, Adam L., Nguyen, Mai K, Edwards, Robert H., Manfredsson, Fredric P., Nakamura, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2017
Materias:	Negative Results
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409983/ https://www.ncbi.nlm.nih.gov/pubmed/28462393 http://dx.doi.org/10.1523/ENEURO.0216-16.2017

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