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A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep
BACKGROUND: A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix(®)) for the treatment and prevention of flea infestation in dogs living wit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410079/ https://www.ncbi.nlm.nih.gov/pubmed/28454576 http://dx.doi.org/10.1186/s13071-017-2145-1 |
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author | Chatzis, Manolis K. Psemmas, Dimitris Papadopoulos, Elias Navarro, Christelle Saridomichelakis, Manolis N. |
author_facet | Chatzis, Manolis K. Psemmas, Dimitris Papadopoulos, Elias Navarro, Christelle Saridomichelakis, Manolis N. |
author_sort | Chatzis, Manolis K. |
collection | PubMed |
description | BACKGROUND: A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep and the secondary aim was to examine the efficacy of this intervention on flea infestation, pruritus and skin lesions of the people in contact with these dogs. METHODS: Thirty dogs living with sheep and infested by at least 10 fleas and all 80 sheep living on the same premises were randomly allocated into equal groups. Group A dogs were treated three times, every 4 weeks, with a spot-on containing 54.5% permethrin and 6.1% fipronil, group A sheep were treated, on the same days, with a pour-on containing 1% deltamethrin, whereas group B dogs were sham-treated and group B sheep were placebo-treated. Flea counting was performed at the beginning of the trial (day 0) and after 14, 28, 56 and 84 days and the first five fleas from each animal were used for species identification. At the same time points, flea infestation, pruritus and skin lesions of the people in contact with the dogs were assessed. RESULTS: The percentage of dogs with zero flea counts was significantly higher in group A than in group B on days 14, 28, 56 and 84 and flea counts were significantly lower in group A dogs than in group B dogs at the same time points. The percent efficacy of the permethrin-fipronil combination was higher than 78% (arithmetic means) or than 96% (geometric means) throughout the study. No adverse reactions were recorded. Between the two flea species found on dogs, Ctenocephalides canis was predominant over C. felis. Flea-infected sheep were not found at the beginning or during the study and no significant changes in flea infestation, pruritus and skin lesions of the people in contact with the dogs were witnessed throughout the study. CONCLUSIONS: A spot-on solution containing 54.5% permethrin and 6.1% fipronil is safe and effective for the treatment and prevention of C. canis and C. felis infestations in dogs living with sheep. |
format | Online Article Text |
id | pubmed-5410079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54100792017-05-02 A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep Chatzis, Manolis K. Psemmas, Dimitris Papadopoulos, Elias Navarro, Christelle Saridomichelakis, Manolis N. Parasit Vectors Research BACKGROUND: A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep and the secondary aim was to examine the efficacy of this intervention on flea infestation, pruritus and skin lesions of the people in contact with these dogs. METHODS: Thirty dogs living with sheep and infested by at least 10 fleas and all 80 sheep living on the same premises were randomly allocated into equal groups. Group A dogs were treated three times, every 4 weeks, with a spot-on containing 54.5% permethrin and 6.1% fipronil, group A sheep were treated, on the same days, with a pour-on containing 1% deltamethrin, whereas group B dogs were sham-treated and group B sheep were placebo-treated. Flea counting was performed at the beginning of the trial (day 0) and after 14, 28, 56 and 84 days and the first five fleas from each animal were used for species identification. At the same time points, flea infestation, pruritus and skin lesions of the people in contact with the dogs were assessed. RESULTS: The percentage of dogs with zero flea counts was significantly higher in group A than in group B on days 14, 28, 56 and 84 and flea counts were significantly lower in group A dogs than in group B dogs at the same time points. The percent efficacy of the permethrin-fipronil combination was higher than 78% (arithmetic means) or than 96% (geometric means) throughout the study. No adverse reactions were recorded. Between the two flea species found on dogs, Ctenocephalides canis was predominant over C. felis. Flea-infected sheep were not found at the beginning or during the study and no significant changes in flea infestation, pruritus and skin lesions of the people in contact with the dogs were witnessed throughout the study. CONCLUSIONS: A spot-on solution containing 54.5% permethrin and 6.1% fipronil is safe and effective for the treatment and prevention of C. canis and C. felis infestations in dogs living with sheep. BioMed Central 2017-04-28 /pmc/articles/PMC5410079/ /pubmed/28454576 http://dx.doi.org/10.1186/s13071-017-2145-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Chatzis, Manolis K. Psemmas, Dimitris Papadopoulos, Elias Navarro, Christelle Saridomichelakis, Manolis N. A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
title | A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
title_full | A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
title_fullStr | A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
title_full_unstemmed | A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
title_short | A field trial of a fixed combination of permethrin and fipronil (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
title_sort | field trial of a fixed combination of permethrin and fipronil (effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410079/ https://www.ncbi.nlm.nih.gov/pubmed/28454576 http://dx.doi.org/10.1186/s13071-017-2145-1 |
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